NOVEL GENE RCS 07

WIPO Patent Application WO2006084732

A3

The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.

CHEVREUX BASTIEN (DE)
MAYER ANNE FRANCOISE (CH)
MEURY ANJA (CH)
MOUNCEY NIGEL JOHN (CH)
SHINJOH MASAKO (JP)

PCT/EP2006/001227

November 02, 2006

February 10, 2006

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DSM IP ASSETS BV (NL)
CHEVREUX BASTIEN (DE)
MAYER ANNE FRANCOISE (CH)
MEURY ANJA (CH)
MOUNCEY NIGEL JOHN (CH)
SHINJOH MASAKO (JP)

C12N9/02

PRUST CHRISTINA ET AL: "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 2, 23 January 2005 (2005-01-23), pages 195 - 200, XP002334994, ISSN: 1087-0156

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