Title:
NOVEL GENE TARGETING METHOD
Document Type and Number:
WIPO Patent Application WO/2016/173556
Kind Code:
A1
Abstract:
A novel gene targeting method and a nucleotide construct for the method. The method integrates a nucleotide construct containing an interference gene in an effective gene targeting region independent of the gene by homologous recombination, thereby improving the targeting efficiency of the gene. The present invention also provides a gene targeting system for gene expression regulation and gene disruption.
Inventors:
JIANG YOUWEI (CN)
LI YUNFEI (CN)
DU ZHENGWEI (CN)
LIANG HUAJUN (CN)
LI YUNFEI (CN)
DU ZHENGWEI (CN)
LIANG HUAJUN (CN)
Application Number:
PCT/CN2016/080788
Publication Date:
November 03, 2016
Filing Date:
April 29, 2016
Export Citation:
Assignee:
HANGZHOU GENEKINE BIOTECH CO LTD (CN)
International Classes:
C12N15/11; C12N1/19; C12N15/81; C12R1/84
Foreign References:
| CN102120967A | 2011-07-13 | |||
| CN1498270A | 2004-05-19 | |||
| CN101679991A | 2010-03-24 |
Other References:
CHEN, ZAO ET AL.: "Enhancement of the Gene Targeting Efficiency of Non-Conventional Yeasts by Increasing Genetic Redundancy", PLOS ONE, vol. 8, no. 3, 7 March 2013 (2013-03-07), pages 1 - 9, XP055325946, ISSN: 1932-6203
See also references of EP 3290519A4
See also references of EP 3290519A4
Attorney, Agent or Firm:
XU & PARTNERS,L LC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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