NOVEL GLUCITOL DERIVATIVE, PRODRUG THEREOF AND SALT THEREOF, AND THERAPEUTIC AGENT CONTAINING THE SAME FOR DIABETES

Title:

NOVEL GLUCITOL DERIVATIVE, PRODRUG THEREOF AND SALT THEREOF, AND THERAPEUTIC AGENT CONTAINING THE SAME FOR DIABETES

Document Type and Number:

WIPO Patent Application WO/2006/011502

Kind Code:

A1

Abstract:

A glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein m is an integer selected among 1-3; R¹ to R⁴ each independently is optionally substituted alkyl, etc.; Ar¹ is optionally substituted naphthyl; and A is optionally substituted heteroaryl), a prodrug of the compound,or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

Inventors:

MATSUOKA HIROHARU (JP)
SATO TSUTOMU (JP)
NISHIMOTO MASAHIRO (JP)
KATO YASUHARU (JP)
SAKAITANI MASAHIRO (JP)
LEE SANG-HAK (KR)

Application Number:

PCT/JP2005/013716

Publication Date:

February 02, 2006

Filing Date:

July 27, 2005

Export Citation:

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)
MATSUOKA HIROHARU (JP)
SATO TSUTOMU (JP)
NISHIMOTO MASAHIRO (JP)
KATO YASUHARU (JP)
SAKAITANI MASAHIRO (JP)
LEE SANG-HAK (KR)

International Classes:

A61K31/381; C07D409/10; A61P3/10; E04F13/08; F16B13/04; F16B13/10

Domestic Patent References:

WO2004013118A1	2004-02-12
WO2002083066A2	2002-10-24
WO2005012326A1	2005-02-10
WO2004080990A1	2004-09-23
WO1997031006A1	1997-08-28

Foreign References:

JP2001288178A	2001-10-16
JP2003511458A	2003-03-25

Other References:

KANAI Y. ET AL: "The Human Kidney Low Affinity Na+/glucose Contransporer SGLT2.", J CLIN INVEST., vol. 93, no. 1, January 1994 (1994-01-01), pages 397 - 404, XP000867742

Attorney, Agent or Firm:

Shamoto, Ichio (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)

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