Title:
NOVEL GLYCOLIPID AND REMEDIAL AGENT FOR AUTOIMMUNE DISEASE CONTAINING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2003/016326
Kind Code:
A1
Abstract:
A glycolipid useful for treatments for autoimmune diseases&semi and a remedy for autoimmune diseases which contains the glycolipid as an active ingredient. The glycolipid is represented by the following formula (I): (I) wherein R1 represents an aldopyranose residue&semi R2 represents hydrogen or hydroxy&semi R3 represents −CH2−, −CH(OH)−CH2−, or −CH=CH−&semi R4 represents hydrogen or CH3&semi x is 0 to 35&semi and y and z each is an integer satisfying 0≤y&plus z≤3.
Inventors:
YAMAMURA TAKASHI (JP)
MIYAKE SACHIKO (JP)
MIYAKE SACHIKO (JP)
Application Number:
PCT/JP2002/008280
Publication Date:
February 27, 2003
Filing Date:
August 14, 2002
Export Citation:
Assignee:
GENOX RESEARCH INC (JP)
JAPAN GOVERNMENT (JP)
YAMAMURA TAKASHI (JP)
MIYAKE SACHIKO (JP)
JAPAN GOVERNMENT (JP)
YAMAMURA TAKASHI (JP)
MIYAKE SACHIKO (JP)
International Classes:
A61K31/7028; A61P37/02; A61P37/06; A61P43/00; C07H15/10; (IPC1-7): C07H15/04; C07H15/10; A61K31/7028; A61P37/02; A61P37/06; A61P43/00
Foreign References:
| EP0609437A1 | 1994-08-10 |
Other References:
KATSUICHI MIYAMOTO ET AL.: "A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 bias of natural killer T cells", NATURE, vol. 413, 4 October 2001 (2001-10-04), pages 531 - 534, XP002958968
HIDEMITSU KITAMURA ET AL.: "alpha-Galactosylceramide induces early B-cell activation through IL-4 production by NKT cells", CELLULAR IMMUNOLOGY, vol. 199, 2000, pages 37 - 42, XP002958969
See also references of EP 1437358A4
HIDEMITSU KITAMURA ET AL.: "alpha-Galactosylceramide induces early B-cell activation through IL-4 production by NKT cells", CELLULAR IMMUNOLOGY, vol. 199, 2000, pages 37 - 42, XP002958969
See also references of EP 1437358A4
Attorney, Agent or Firm:
Shimoda, Akira (Kyobashi-Nichiei Biru 3-4, Kyobashi 3-chom, Chuo-ku Tokyo, JP)
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