Title:
NOVEL GLYCOLIPID AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/099999
Kind Code:
A1
Abstract:
It is intended to provide a compound represented by the following general formula (1)
or its salt: (1) wherein each symbol is as defined in the description. The above-described compound
or its salt can preferentially induce the production of IL-4 that is one of cytokines
controlling the functions of immunocytes, which makes them useful in preventing
and treating autoimmune diseases, infections and so on and preventing and treating
diseases caused by the hyperfunction of Th1 cells. .
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Inventors:
TASHIRO TAKUYA (JP)
MORI KENJI (JP)
FUHSHUKU KEN-ICHI (JP)
TANIGUCHI MASARU (JP)
SEINO KENICHIRO (JP)
MORI KENJI (JP)
FUHSHUKU KEN-ICHI (JP)
TANIGUCHI MASARU (JP)
SEINO KENICHIRO (JP)
Application Number:
PCT/JP2007/053759
Publication Date:
September 07, 2007
Filing Date:
February 28, 2007
Export Citation:
Assignee:
RIKEN (JP)
TASHIRO TAKUYA (JP)
MORI KENJI (JP)
FUHSHUKU KEN-ICHI (JP)
TANIGUCHI MASARU (JP)
SEINO KENICHIRO (JP)
TASHIRO TAKUYA (JP)
MORI KENJI (JP)
FUHSHUKU KEN-ICHI (JP)
TANIGUCHI MASARU (JP)
SEINO KENICHIRO (JP)
International Classes:
C07H15/04; A61K31/7028; A61P25/00; A61P29/00; A61P31/00; A61P37/00; A61P37/06; A61P43/00
Domestic Patent References:
| WO2003016326A1 | 2003-02-27 |
Foreign References:
| JP2004217601A | 2004-08-05 |
Other References:
NAOI M. ET AL.: "Alteration of the substrate specificity of Aspergillus oryzae beta-galactosidase by modification with polyethylene glycol", JOURNAL OF APPLIED BIOCHEMISTRY, vol. 6, no. 1-2, 1984, pages 91 - 102, XP003024543
NAOI M. ET AL.: "A sensitive assay for glucocerebroside beta-glucosidase by high-performance liquid chromatography using 1-O-glucosyl-2-N-(1-dimethylaminonaphthalene-5-sulfonyl)sphingosine as substrate", JOURNAL OF APPLIED BIOCHEMISTRY, vol. 3, no. 6, 1981, pages 544 - 551, XP003024544
AGMON V. ET AL.: "Synthesis and use of novel fluorescent glycosphingolipids of estimating beta-glucosidase activity in vitro in the absence of detergents and subtyping Gaucher disease variants following administration into intact cells", BIOCHIMICA ET BIOPHYSICA ACTA, LIPIDS AND LIPID METABOLISM, vol. 1170, no. 1, 1993, pages 72 - 79, XP003024545
NAOI M. ET AL.: "A sensitive assay for glucocerebroside beta-glucosidase by high-performance liquid chromatography using 1-O-glucosyl-2-N-(1-dimethylaminonaphthalene-5-sulfonyl)sphingosine as substrate", JOURNAL OF APPLIED BIOCHEMISTRY, vol. 3, no. 6, 1981, pages 544 - 551, XP003024544
AGMON V. ET AL.: "Synthesis and use of novel fluorescent glycosphingolipids of estimating beta-glucosidase activity in vitro in the absence of detergents and subtyping Gaucher disease variants following administration into intact cells", BIOCHIMICA ET BIOPHYSICA ACTA, LIPIDS AND LIPID METABOLISM, vol. 1170, no. 1, 1993, pages 72 - 79, XP003024545
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka, JP)
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