Title:
NOVEL GLYCOSIDES COMPRISING PENTOSE MONO-, DI-, TRI-, OR OLIGOSACCHARIDES AND PHYTOSTEROLS AND/OR PHYTOSTANOLS
Document Type and Number:
WIPO Patent Application WO2001032679
Kind Code:
A3
Abstract:
A novel glycoside compound for use in treating or preventing cardiovascular disease and it's underlying conditions such as atherosclersis and hypercholeterolemia comprises a carbohydrate moiety and a non-carbohydrate moiety wherein the carbohydrate moiety is selected from the group consisting of pentose monosaccharides, disaccharides, trisaccharides and oligosaccharides and their acylated derivatives and the non-carbohydrate moiety is either a phytosterol, a phytostanol or a derivative thereof.
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Inventors:
KUTNEY JAMES P
MILANOVA RADKA K
CHEN HONMING
STOYNOV NIKOLAY MINTCHEV
MILANOVA RADKA K
CHEN HONMING
STOYNOV NIKOLAY MINTCHEV
Application Number:
PCT/CA2000/001272
Publication Date:
October 25, 2001
Filing Date:
November 01, 2000
Export Citation:
Assignee:
FORBES MEDI TECH INC (CA)
International Classes:
C07J17/00; (IPC1-7): C07J17/00; A61K31/58
Domestic Patent References:
| WO1993007167A1 | 1993-04-15 | |||
| WO1994000480A1 | 1994-01-06 |
Foreign References:
| US4929603A | 1990-05-29 | |||
| US4188379A | 1980-02-12 | |||
| US4254111A | 1981-03-03 | |||
| GB1298047A | 1972-11-29 | |||
| US3933789A | 1976-01-20 | |||
| GB2304106A | 1997-03-12 |
Other References:
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KALINOVSKAYA, N. I. ET AL: "Steroidal glycosides from Far East holothurian Stichopus japonicus Selenka", XP002167096, retrieved from STN Database accession no. 91:207739
MAKARIEVA, TATYANA N. ET AL: "Biosynthetic studies of marine lipids. 42. Biosynthesis of steroid and triterpenoid metabolites in the sea cucumber Eupentacta fraudatrix", STEROIDS (1993), 58(11), 508-17, XP002167093
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DELLA GRECA, MARINA ET AL: "Studies on aquatic plants. Part 19. Acylglycosyl sterols from Pistia stratiotes", XP002167097, retrieved from STN Database accession no. 115:110661
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TANDON, MAMTA ET AL: "Steroid glycosides from Asparagus adscendens", XP002167098, retrieved from STN Database accession no. 114:78620
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; IRIBARREN, ADOLFO M. ET AL: "Sitosterol 3-O-.beta.-D-xylopyranoside from Bauhinia candicans", XP002167099, retrieved from STN Database accession no. 102:3244
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIM, HA-KUNG ET AL: "Synthesis of stigmasterol-.alpha.-L-arabinopyranoside", XP002167100, retrieved from STN Database accession no. 74:142276
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ANJANEYULU, V. ET AL: "Isolation of 24-methylenecholesterol-3-O-.alpha.-L-fucopyranoside and 24-methylenecholest-7-ene-3.beta.,6.alpha.,9.alpha.,11.alpha.- tetrol from a soft coral of the Andaman and Nicobar Islands", XP002167101, retrieved from STN Database accession no. 120:187483
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALIAGA, A. ET AL: "Identification of sterols and fatty acids from squill bulbs (Urginea maritima)", XP002167102, retrieved from STN Database accession no. 110:36742
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AGNIHOTRI, VINOD KUMAR: "Poriferasterol-3-rhamnoside, a new saponin from the stem bark of Amoora rohituka", XP002167103, retrieved from STN Database accession no. 108:72082
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SRIVASTAVA, SAVITRI D.: "Chemical constituents of Cleome viscosa", XP002167104, retrieved from STN Database accession no. 96:214280
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CHAO, YU-CHOU ET AL: "Extracts from the heartwood of Ali-shan elm", XP002167105, retrieved from STN Database accession no. 94:1995
CHEMICAL ABSTRACTS, vol. 98, no. 7, 14 February 1983, Columbus, Ohio, US; abstract no. 46750, V. N. MIRANOVA ET AL: "Hypolipemic effect of beta-sitosterol beta-D-glucoside" page 55; column 1; XP002167095
DENINNO MICHAEL P ET AL: "Steroidal glycoside cholesterol absorption inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 16, 1997, pages 2547 - 2554, XP002167094, ISSN: 0022-2623
MAKARIEVA, TATYANA N. ET AL: "Biosynthetic studies of marine lipids. 42. Biosynthesis of steroid and triterpenoid metabolites in the sea cucumber Eupentacta fraudatrix", STEROIDS (1993), 58(11), 508-17, XP002167093
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DELLA GRECA, MARINA ET AL: "Studies on aquatic plants. Part 19. Acylglycosyl sterols from Pistia stratiotes", XP002167097, retrieved from STN Database accession no. 115:110661
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TANDON, MAMTA ET AL: "Steroid glycosides from Asparagus adscendens", XP002167098, retrieved from STN Database accession no. 114:78620
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; IRIBARREN, ADOLFO M. ET AL: "Sitosterol 3-O-.beta.-D-xylopyranoside from Bauhinia candicans", XP002167099, retrieved from STN Database accession no. 102:3244
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIM, HA-KUNG ET AL: "Synthesis of stigmasterol-.alpha.-L-arabinopyranoside", XP002167100, retrieved from STN Database accession no. 74:142276
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ANJANEYULU, V. ET AL: "Isolation of 24-methylenecholesterol-3-O-.alpha.-L-fucopyranoside and 24-methylenecholest-7-ene-3.beta.,6.alpha.,9.alpha.,11.alpha.- tetrol from a soft coral of the Andaman and Nicobar Islands", XP002167101, retrieved from STN Database accession no. 120:187483
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALIAGA, A. ET AL: "Identification of sterols and fatty acids from squill bulbs (Urginea maritima)", XP002167102, retrieved from STN Database accession no. 110:36742
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AGNIHOTRI, VINOD KUMAR: "Poriferasterol-3-rhamnoside, a new saponin from the stem bark of Amoora rohituka", XP002167103, retrieved from STN Database accession no. 108:72082
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SRIVASTAVA, SAVITRI D.: "Chemical constituents of Cleome viscosa", XP002167104, retrieved from STN Database accession no. 96:214280
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CHAO, YU-CHOU ET AL: "Extracts from the heartwood of Ali-shan elm", XP002167105, retrieved from STN Database accession no. 94:1995
CHEMICAL ABSTRACTS, vol. 98, no. 7, 14 February 1983, Columbus, Ohio, US; abstract no. 46750, V. N. MIRANOVA ET AL: "Hypolipemic effect of beta-sitosterol beta-D-glucoside" page 55; column 1; XP002167095
DENINNO MICHAEL P ET AL: "Steroidal glycoside cholesterol absorption inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 16, 1997, pages 2547 - 2554, XP002167094, ISSN: 0022-2623
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