Title:
NOVEL GUANOSINE-RICH MODIFIED OLIGONUCLEOTIDES AND ANTIPROLIFERATIVE ACTIVITY THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/002200
Kind Code:
A2
Abstract:
The present invention relates to a novel modified oligonucleotide comprising at least one guanosine molecule and a modified nucleic acid with therapeutic efficacies. The present invention also relates to a pharmaceutical composition having cell apoptotic activity against cancer cells for preventing or treating cancer comprising a guanosine-rich modified oligonucleotide with at least one therapeutically effective modified nucleic acid (N), or its pharmaceutically acceptable salt as active ingredient.
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Inventors:
LEE SOO JIN (KR)
MOON SUNG HWAN (KR)
MOON SUNG HWAN (KR)
Application Number:
PCT/KR2010/004202
Publication Date:
January 06, 2011
Filing Date:
June 29, 2010
Export Citation:
Assignee:
APTABIO THERAPEUTICS INC (KR)
LEE SOO JIN (KR)
MOON SUNG HWAN (KR)
LEE SOO JIN (KR)
MOON SUNG HWAN (KR)
International Classes:
A61K31/7115; C07H19/06; A61P35/00; C07H21/00; C12N15/11
Domestic Patent References:
| WO2003002592A1 | 2003-01-09 | |||
| WO1994008053A1 | 1994-04-14 | |||
| WO2003087317A2 | 2003-10-23 |
Foreign References:
| US7312082B2 | 2007-12-25 | |||
| US7314926B1 | 2008-01-01 | |||
| US20070105805A1 | 2007-05-10 | |||
| US5567604A | 1996-10-22 | |||
| US6994959B1 | 2006-02-07 | |||
| US5457187A | 1995-10-10 | |||
| US5614505A | 1997-03-25 | |||
| US6323185B1 | 2001-11-27 | |||
| US7157436B2 | 2007-01-02 | |||
| US7199228B2 | 2007-04-03 |
Other References:
GLEAVE ET AL., NAT REV CANCER, 2005, pages 468 - 479
CASTANOTTO ET AL., NATURE, 2008, pages 426 - 433
SULLENGER ET AL., NATURE, 2002, pages 252 - 258
KAUR ET AL., EXPERT OPIN INVESTIG DRUGS, 2008, pages 43 - 60
JURK M ET AL., BIODRUGS, 2007, pages 387 - 401
TOMITA ET AL., CLIN EXP NEPHROL., 2007, pages 7 - 17
CHRISTOPHER R. IRESON ET AL., MOLECULAR CANCER THERAPY, 2006, pages 2957 - 2962
NAIJIE JING ET AL., CANCER RESEARCH, 2004, pages 6603 - 6609
CHRISTOPHE MARCHAND ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, pages 8906 - 8911
JULIAN LEON HUPPERT, CHEMICAL SOCIETY REVIEWS, vol. 37, 2008, pages 1375 - 1384
PAULA J. BATES ET AL., EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2009, pages 151 - 164
HAIYAN QI ET AL., CANCER RES, 2006, pages 11808 - 11816
ANNA AROLA ET AL., CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, pages 1405 - 1415
PAULA J. BATES ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, pages 26369 - 26377
BRUNA ET AL., FEBS, 2006, pages 1350 - 1361
CHERYL A. STODDART ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, pages 2113 - 2115
MICHAEL SKOGEN ET AL., BMC NEUROSCIENCE, vol. 7, 2006, pages 65
CHRISTOPHER R. IRESON ET AL., MOL CANCER THER., vol. 5, no. 12, December 2006 (2006-12-01), pages 2957 - 62
PAULA J. BATES, EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2009, pages 151 - 164
PIEDO ET AL., J CLIN ONCOL, 1988, pages 1953 - 1664
THOMAS ET AL., CLIN EXP PHARMACOL PHYSIOL., 1998, pages 887 - 895
HEIDELBERGER ET AL., NATURE, vol. 179, 1957, pages 663 - 666
LONGLEY ET AL., NAT REV CANCER, 2003, pages 330 - 338
BEUMER ET AL., CANCER CHEMOTHER PHARMACOL, 2008, pages 363 - 368
SONG ET AL., CLINICAL CANCER RESEARCH, 1997, pages 901 - 909
GMEINER ET AL., J. ORG. CHEM., 1994, pages 5779 - 5783
SCHMIDT ET AL., NUCLEIC ACIDS RESEARCH, 1992, pages 2421 - 2426
STOLARSKI ET AL., BIOCHEMISTRY, vol. 31, 1992, pages 7027 - 7042
GMEINER ET AL., NUCL. NUCT., 1995, pages 243 - 253
FRITZ ECKSTEIN ET AL.: "Oligonucleotides and Analogues: A Practical Approach", 1991, IRL PRESS
CHERYL A STODDART ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, pages 2113 - 2115
VIRNA DAPIC ET AL., BIOCHEMISTRY, 2002, pages 3676 - 3685
NAIJIE JING ET AL., BIOCHEMISTRY, vol. 41, 2002, pages 5397 - 5403
NAIJIE JING ET AL., CANCER RESEARCH, 2004, pages 6603 - 6609
HAIYAN QI ET AL., CANCER RESEARCH, 2006, pages 11808 - 11816
YUNTENG ET AL., CANCER RESEARCH, 2007, pages 10491 - 10500
BRUNA SCAGGIANTE ET AL., FEBS JOURNAL, 2006, pages 1350 - 1361
JULIE E. REED ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, pages 5992 - 5993
JEFFREY S. BISHOP ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, pages 5698 - 5703
CHRISTOPHE MARCHAND ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, pages 8906 - 8911
JUN-ICHIRO SUZUKI ET AL., JOURNAL OF VIROLOGY, 2002, pages 3015 - 3022
VIRNA DAPIC ET AL., NUCLEIC ACIDS RESEARCH, 2003, pages 2097 - 2107
AMBER GOODCHILD ET AL., NUCLEIC ACID RESEARCH, 2007, pages 4562 - 4572
M. LU; Q. GUO; N.R.KALLENBACK, BIOCHEMISTRY, vol. 31, 1992, pages 2455
P. BALAGURUMOORTHY; S.K. BRAHMACHARI, NUCLEIC ACIDS RES., vol. 20, 1992, pages 4061
PROC. NATL. ACAD. SCI. U.S.A., vol. 91, 1994, pages 7658 - 7662
BIOCHEMISTRY, vol. 36, 1997, pages 12498
BIOCHEMISTRY, vol. 41, 2002, pages 3676
JBC, 1999, pages 26369
M. LU; Q. GUO; N. R. KALLENBACK, BIOCHEMISTRY, vol. 31, 1992, pages 2455
P. BALAGURUMOORTHY; S. K. BRAHMACHARI, NUCLEIC ACIDS RES., vol. 20, 1992, pages 4061
See also references of EP 2448952A4
CASTANOTTO ET AL., NATURE, 2008, pages 426 - 433
SULLENGER ET AL., NATURE, 2002, pages 252 - 258
KAUR ET AL., EXPERT OPIN INVESTIG DRUGS, 2008, pages 43 - 60
JURK M ET AL., BIODRUGS, 2007, pages 387 - 401
TOMITA ET AL., CLIN EXP NEPHROL., 2007, pages 7 - 17
CHRISTOPHER R. IRESON ET AL., MOLECULAR CANCER THERAPY, 2006, pages 2957 - 2962
NAIJIE JING ET AL., CANCER RESEARCH, 2004, pages 6603 - 6609
CHRISTOPHE MARCHAND ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, pages 8906 - 8911
JULIAN LEON HUPPERT, CHEMICAL SOCIETY REVIEWS, vol. 37, 2008, pages 1375 - 1384
PAULA J. BATES ET AL., EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2009, pages 151 - 164
HAIYAN QI ET AL., CANCER RES, 2006, pages 11808 - 11816
ANNA AROLA ET AL., CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, pages 1405 - 1415
PAULA J. BATES ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, pages 26369 - 26377
BRUNA ET AL., FEBS, 2006, pages 1350 - 1361
CHERYL A. STODDART ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, pages 2113 - 2115
MICHAEL SKOGEN ET AL., BMC NEUROSCIENCE, vol. 7, 2006, pages 65
CHRISTOPHER R. IRESON ET AL., MOL CANCER THER., vol. 5, no. 12, December 2006 (2006-12-01), pages 2957 - 62
PAULA J. BATES, EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2009, pages 151 - 164
PIEDO ET AL., J CLIN ONCOL, 1988, pages 1953 - 1664
THOMAS ET AL., CLIN EXP PHARMACOL PHYSIOL., 1998, pages 887 - 895
HEIDELBERGER ET AL., NATURE, vol. 179, 1957, pages 663 - 666
LONGLEY ET AL., NAT REV CANCER, 2003, pages 330 - 338
BEUMER ET AL., CANCER CHEMOTHER PHARMACOL, 2008, pages 363 - 368
SONG ET AL., CLINICAL CANCER RESEARCH, 1997, pages 901 - 909
GMEINER ET AL., J. ORG. CHEM., 1994, pages 5779 - 5783
SCHMIDT ET AL., NUCLEIC ACIDS RESEARCH, 1992, pages 2421 - 2426
STOLARSKI ET AL., BIOCHEMISTRY, vol. 31, 1992, pages 7027 - 7042
GMEINER ET AL., NUCL. NUCT., 1995, pages 243 - 253
FRITZ ECKSTEIN ET AL.: "Oligonucleotides and Analogues: A Practical Approach", 1991, IRL PRESS
CHERYL A STODDART ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, pages 2113 - 2115
VIRNA DAPIC ET AL., BIOCHEMISTRY, 2002, pages 3676 - 3685
NAIJIE JING ET AL., BIOCHEMISTRY, vol. 41, 2002, pages 5397 - 5403
NAIJIE JING ET AL., CANCER RESEARCH, 2004, pages 6603 - 6609
HAIYAN QI ET AL., CANCER RESEARCH, 2006, pages 11808 - 11816
YUNTENG ET AL., CANCER RESEARCH, 2007, pages 10491 - 10500
BRUNA SCAGGIANTE ET AL., FEBS JOURNAL, 2006, pages 1350 - 1361
JULIE E. REED ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, pages 5992 - 5993
JEFFREY S. BISHOP ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, pages 5698 - 5703
CHRISTOPHE MARCHAND ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, pages 8906 - 8911
JUN-ICHIRO SUZUKI ET AL., JOURNAL OF VIROLOGY, 2002, pages 3015 - 3022
VIRNA DAPIC ET AL., NUCLEIC ACIDS RESEARCH, 2003, pages 2097 - 2107
AMBER GOODCHILD ET AL., NUCLEIC ACID RESEARCH, 2007, pages 4562 - 4572
M. LU; Q. GUO; N.R.KALLENBACK, BIOCHEMISTRY, vol. 31, 1992, pages 2455
P. BALAGURUMOORTHY; S.K. BRAHMACHARI, NUCLEIC ACIDS RES., vol. 20, 1992, pages 4061
PROC. NATL. ACAD. SCI. U.S.A., vol. 91, 1994, pages 7658 - 7662
BIOCHEMISTRY, vol. 36, 1997, pages 12498
BIOCHEMISTRY, vol. 41, 2002, pages 3676
JBC, 1999, pages 26369
M. LU; Q. GUO; N. R. KALLENBACK, BIOCHEMISTRY, vol. 31, 1992, pages 2455
P. BALAGURUMOORTHY; S. K. BRAHMACHARI, NUCLEIC ACIDS RES., vol. 20, 1992, pages 4061
See also references of EP 2448952A4
Attorney, Agent or Firm:
HALLA PATENT & LAW FIRM (KTB Network Bldg.826-14, Yeoksam-don, Kangnam-ku Seoul 135-769, KR)
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