NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME

Title:

NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME

Document Type and Number:

WIPO Patent Application WO/2020/054670

Kind Code:

A1

Abstract:

To provide a compound for selectively inhibiting Nav1.7 rather than Nav1.5. A heteroaromatic amide derivative or a salt thereof which is highly effective for pain and various other Nav1.7-related diseases, the heteroaromatic amide derivative being represented by general formula (I). [In the formula: X1-X2 represent N-C or C-N; Y1, Y2, Y3, and Y4 represent -CH2-, -CR4aH-, -O-, or the like; Z1 represents -O- or the like; the ring A is a 3-7-membered monocyclic aromatic ring or the like; R1a and R1b are hydrogen atoms, halogen atoms, or the like; R2 is a hydrogen atom or the like; R3a, R3b, and R3c are hydrogen atoms or C1-C6 haloalkyl groups or the like which may be substituted; R4a, R4b, and R4c are C1-C6 haloalkyl groups or C1-C6 haloalkoxy groups or the like which may be substituted; R5a is a hydrogen atom or the like; R5a and R5b join together to form -CH2O- or the like; R6a and R6b are hydrogen atoms or the like; and n is 1 or 2.]

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Inventors:

AKAHOSHI ISSEI (JP)
SUMIKAWA YOSHITAKE (JP)
FURUTA SADAYOSHI (JP)
FUKUSHIMA KEIICHIRO (JP)
IMAZU TAKUYA (JP)
KOTAKA RYOTA (JP)

Application Number:

PCT/JP2019/035393

Publication Date:

March 19, 2020

Filing Date:

September 09, 2019

Export Citation:

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Assignee:

KAKEN PHARMA CO LTD (JP)

International Classes:

C07D471/04; A61K31/424; A61K31/437; A61K31/4439; A61K31/444; A61K31/454; A61K31/497; A61K31/4985; A61K31/506; A61K31/519; A61K31/5365; A61K31/5377; A61K31/5383; A61K31/553; A61P17/04; A61P25/00; A61P25/02; A61P25/04; A61P29/00; A61P43/00; C07D487/04; C07D498/04

Domestic Patent References:

WO2018109097A1	2018-06-21
WO2017004500A1	2017-01-05
WO2017145013A1	2017-08-31

Foreign References:

US20090186902A1	2009-07-23
JP2016526571A	2016-09-05

Other References:

DATABASE CAS [online] 31 August 2018 (2018-08-31), retrieved from STN Database accession no. 2242295-07-2
DATABASE CAS [online] 30 August 2018 (2018-08-30), retrieved from STN Database accession no. 2241890-76-4
DATABASE CAS [online] 6 July 2015 (2015-07-06), retrieved from STN Database accession no. 1795487-06-7
DATABASE CAS [online] 26 June 2015 (2015-06-26), retrieved from STN Database accession no. 1789032-35-4
DATABASE CAS [online] 3 July 2012 (2012-07-03), retrieved from STN Database accession no. 1380773-67-0
DATABASE CAS [online] 8 June 2015 (2015-06-08), retrieved from STN Database accession no. 1775525-83-1

Attorney, Agent or Firm:

ASAMURA PATENT OFFICE, P.C. (JP)

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