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Title:
NOVEL HETEROAROMATIC SILICON-FLUORIDE-ACCEPTORS USEFUL FOR 18F LABELING OF MOLECULES AND BIOMOLECULES, AND METHODS OF PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2016/191424
Kind Code:
A3
Abstract:
The present invention includes novel compounds and compositions including heteroaromatic Silicon-Fluoride- Acceptors, which are useful for PET scanning. The present invention further includes a novel method of 18F imaging for PET scanning, the method comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic SiFAs. In one embodiment the invention is practiced in the form of a kit.

Inventors:
WALDMANN, Christopher, Martin (3013 Colorado Ave, Apt.cSanta Monica, CA, 90404, US)
TOUTOV, Anton, A. (385 S. Catalina Ave, Apt. 232Pasadena, CA, 91106, US)
MURPHY, Jennifer, Marie (1049 Colina Way, Los Angeles, CA, 90077, US)
GRUBBS, Robert, H. (1700 Spruce Street, South Pasadena, CA, 91030, US)
Application Number:
US2016/033923
Publication Date:
December 29, 2016
Filing Date:
May 24, 2016
Export Citation:
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Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1111 Franklin Street, Twelfth FloorOakland, CA, 94607-5200, US)
International Classes:
C07F7/08; A61K51/04; C07F13/00; C07F19/00
Domestic Patent References:
WO2012087908A12012-06-28
WO2008040441A22008-04-10
Other References:
DIALER, L. 0. ET AL.: "Studies toward the development of new silicon- containing building blocks for the direct 18F-labeling of peptides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 19, 2013, pages 7552 - 7563, XP055179972
NEUGEBAUER, P. ET AL.: "Sliylturans and Bis(silyl)butadiynes - Synthesis, Lithium Derivatives, Crystal Structure", ZEITSCHRIFT FUR NATURFORSCHUNG B, vol. 55, no. 10, 2000, pages 913 - 923
FRENZEL, A. ET AL.: "Indolyl- and Pyrrolylsilanes - Syntheses and Crystal Structures", ZEITSCHRIFT FUR NATURFORSCHUNG B, vol. 50, no. 11, 1995, pages 1658 - 1664, XP055341046
BAUM, C. ET AL.: "Lithium-silylindolide als Precursor fur 1,2-, 1,3-Bis(silyl)indole und Bis(indol-1,3-yl)silane", ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, vol. 625, no. 12, 1999, pages 1969 - 1978, XP055341052
Attorney, Agent or Firm:
GHIDU, Victor P. et al. (Riverside Law, LLPGlenhardie Corporate Center,1285 Dummers Lane, Suite 20, Wayne PA, 19087, US)
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