Title:
NOVEL HETEROARYL COMPOUND, ENANTIOMER, DIASTEREOMER OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND ANTIVIRAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/062978
Kind Code:
A1
Abstract:
The present invention relates to a novel heteroaryl compound, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, and an antiviral composition comprising the same as an active ingredient. The novel compounds represented by formula (I) or formula (II) according to the present invention are remarkably superior in antiviral activity against an influenza virus, and furthermore, have low cytotoxicity and thus low adverse effects on a human body. Therefore, a pharmaceutical composition containing the same as an active ingredient can be effectively used for the prevention or treatment of diseases caused by an influenza virus infection.
Inventors:
MIN JI YOUNG (KR)
CHANG SO YOUNG (KR)
LEE JI HYE (KR)
KANG SUN HEE (KR)
KONG SUN JU (KR)
JO SU YEON (KR)
PARK KAAPJOO (KR)
KIM YOUNG MI (KR)
CHOI JUNGHWAN (KR)
CHANG SO YOUNG (KR)
LEE JI HYE (KR)
KANG SUN HEE (KR)
KONG SUN JU (KR)
JO SU YEON (KR)
PARK KAAPJOO (KR)
KIM YOUNG MI (KR)
CHOI JUNGHWAN (KR)
Application Number:
PCT/KR2017/011091
Publication Date:
April 05, 2018
Filing Date:
September 29, 2017
Export Citation:
Assignee:
PASTEUR INSTITUT KOREA (KR)
International Classes:
C07D271/113; A01N43/50; A23L33/10; C07D249/08; C07D285/135; C07D403/06; C07D413/06; C07D417/06; C11D3/48
Domestic Patent References:
| WO2013025858A1 | 2013-02-21 |
Foreign References:
| EP2390252A1 | 2011-11-30 | |||
| CN103880836A | 2014-06-25 |
Other References:
DATABASE Registry [O] 29 May 2008 (2008-05-29), retrieved from STN Database accession no. 1023577-60-7
DATABASE Registry [O] 5 July 2015 (2015-07-05), retrieved from STN Database accession no. 1793881-10-3
FLEFEL, E. M. ET AL.: "Heterocyclic Compounds Based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)-furanone: Anti-avian Influenza Virus (H5N1) Activity", ACTA PHARM., vol. 62, 2012, pages 593 - 606, XP055497796
DATABASE Registry [O] 5 July 2015 (2015-07-05), retrieved from STN Database accession no. 1793881-10-3
FLEFEL, E. M. ET AL.: "Heterocyclic Compounds Based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)-furanone: Anti-avian Influenza Virus (H5N1) Activity", ACTA PHARM., vol. 62, 2012, pages 593 - 606, XP055497796
Attorney, Agent or Firm:
PHIL & ONZI INT'L PATENT & LAW FIRM (KR)
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