Title:
NOVEL HETEROCYCLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/212256
Kind Code:
A1
Abstract:
The present invention relates to a novel heterocycle derivative, a salt thereof, or an isomer thereof. More specifically, the present invention relates to a novel heterocycle derivative effective for the therapy of hair loss such as androgenic alopecia and alopecia areata and having an excellent preventive effect of hair loss, a salt or isomer thereof, and a composition comprising same as an effective ingredient for prevention of hair loss.
Inventors:
HONG WOO SANG (KR)
CHA JOO YOUNG (KR)
CHOI SUN EA (KR)
IM ISAK (KR)
YUN CHI-HO (KR)
JANG JAE HO (KR)
JUNG CHAE LIM (KR)
CHIN SEI HO (KR)
KIM JIKNYEO (KR)
KIM JOONGSOO (KR)
LEE SANG HAK (KR)
CHA JOO YOUNG (KR)
CHOI SUN EA (KR)
IM ISAK (KR)
YUN CHI-HO (KR)
JANG JAE HO (KR)
JUNG CHAE LIM (KR)
CHIN SEI HO (KR)
KIM JIKNYEO (KR)
KIM JOONGSOO (KR)
LEE SANG HAK (KR)
Application Number:
PCT/KR2019/005261
Publication Date:
November 07, 2019
Filing Date:
May 02, 2019
Export Citation:
Assignee:
JW PHARMACEUTICAL CORP (KR)
International Classes:
C07D471/04; A61K8/49; A61K31/437; A61P17/14; A61Q7/00
Domestic Patent References:
| WO2003068773A1 | 2003-08-21 | |||
| WO2006091737A1 | 2006-08-31 | |||
| WO2004018473A2 | 2004-03-04 | |||
| WO2013067302A1 | 2013-05-10 | |||
| WO2018208132A1 | 2018-11-15 |
Foreign References:
| JPH03287513A | 1991-12-18 | |||
| KR20100121222A | 2010-11-17 | |||
| KR20150085962A | 2015-07-27 |
Other References:
MARTEL J.L.BADRI T.: "Anatomy, Head, Hair, Follicle. Book", 10 January 2018, STATPEARLS PUBLISHING LLC
BOTCHKAREV V.A.KISHIMOTO J.: "Molecular control of epithelial-mesenchymal interactions during hair follicle cycling", J INVESTIG. DERMATOL. SYMP. PROC., vol. 8, 2003, pages 46 - 55, XP055058772, DOI: 10.1046/j.1523-1747.2003.12171.x
BOTCHKAREV V.A.BATCHKAREVA N.V.NAKAMURA M: "Noggin is required for induction of the hair follicle growth phase in postnatal skin", FASEB J, vol. 15, 2001, pages 2205 - 2214, XP001161202, DOI: 10.1096/fj.01-0207com
MINGXING LEILI YANGCHENG-MING CHUONG: "Getting to the Core of the Dermal Papilla", J. INVEST. DERMATOL., vol. 137, 2017, pages 2250 - 2253
KWACK M.H.SUNG Y.K.CHUNG E.J.IM S.U.AHN J.S.KIM M.K.KIM J.C.: "Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes", J. INVEST. DERMATOL., vol. 128, 2008, pages 262 - 269
See also references of EP 3822270A4
BOTCHKAREV V.A.KISHIMOTO J.: "Molecular control of epithelial-mesenchymal interactions during hair follicle cycling", J INVESTIG. DERMATOL. SYMP. PROC., vol. 8, 2003, pages 46 - 55, XP055058772, DOI: 10.1046/j.1523-1747.2003.12171.x
BOTCHKAREV V.A.BATCHKAREVA N.V.NAKAMURA M: "Noggin is required for induction of the hair follicle growth phase in postnatal skin", FASEB J, vol. 15, 2001, pages 2205 - 2214, XP001161202, DOI: 10.1096/fj.01-0207com
MINGXING LEILI YANGCHENG-MING CHUONG: "Getting to the Core of the Dermal Papilla", J. INVEST. DERMATOL., vol. 137, 2017, pages 2250 - 2253
KWACK M.H.SUNG Y.K.CHUNG E.J.IM S.U.AHN J.S.KIM M.K.KIM J.C.: "Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes", J. INVEST. DERMATOL., vol. 128, 2008, pages 262 - 269
See also references of EP 3822270A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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