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Patent Searching and Data


Title:
NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2017/186148
Kind Code:
A1
Abstract:
Disclosed is a compound of Formula (Ⅰ) or a pharmaceutically acceptable salt thereof, wherein the variables are described herein. Also disclosed is a process for the preparation of compounds, their pharmaceutical compositions comprising the same as an active ingredient, methods using said compositions in the treatment of various disorders, and use of the compounds in the manufacture of a medicament in inhibition of the enzymatic activities of ABL1, ABL2 and related chimeric proteins.

Inventors:
LI LIANHAI (CA)
YU CHUNRONG (US)
HUANG HAIHONG (CN)
Application Number:
PCT/CN2017/082243
Publication Date:
November 02, 2017
Filing Date:
April 27, 2017
Export Citation:
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Assignee:
ASTAR BIOTECH LLC (US)
LI LIANHAI (CA)
YU CHUNRONG (US)
HUANG HAIHONG (CN)
International Classes:
C07D401/14; A61K31/4439; C07D401/04; C07D401/10; C07D403/10; C07D403/14; C07D471/04; C07D487/04; C07D487/10; C07D491/10; C07D498/08
Foreign References:
CN104379574A2015-02-25
CN104302634A2015-01-21
CN104302638A2015-01-21
CN104334529A2015-02-04
Other References:
See also references of EP 3448852A4
Attorney, Agent or Firm:
BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE (CN)
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