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Patent Searching and Data


Title:
NOVEL HETEROCYCLIC DERIVATIVE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/004258
Kind Code:
A1
Abstract:
The present invention relates to a novel heterocyclic derivative compound and a use thereof and, more particularly, to a novel heterocyclic derivative compound having selective inhibitory activity against a fibroblast growth factor receptor (FGFR), and a pharmaceutical composition comprising the same for preventing or treating various diseases associated with the FGFR.

Inventors:
LEE MOON SUB (KR)
BYUN EUN YOUNG (KR)
KIM JI SOOK (KR)
KIM WON JEOUNG (KR)
KIM NAM DU (KR)
JUNG SEUNG HYUN (KR)
AHN YOUNG GIL (KR)
Application Number:
PCT/KR2017/006849
Publication Date:
January 04, 2018
Filing Date:
June 28, 2017
Export Citation:
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Assignee:
HANMI PHARMACEUTICAL CO LTD (KR)
International Classes:
C07D487/14; A61K9/20; A61K9/48; A61K31/519; C07D471/14
Domestic Patent References:
WO2014172425A12014-10-23
WO2001029042A12001-04-26
Foreign References:
KR20040099384A2004-11-26
US20140088100A12014-03-27
Other References:
CHEN, P. ET AL.: "Imidazoquinoxaline Src-family Kinase p56Lck Inhibitors: SAR, QSAR, and the Discovery of (S)-N-(2-chloro-6-methylphenyl)-2- (3-methyl-1-piperazinyl) Imidazo-[l, 5-a] Pyrido [3, 2-e] Pyrazin-6-Amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 18, 2004, pages 4517 - 4529, XP002449285
See also references of EP 3476846A4
DAILEY ET AL., CYTOKINE GROWTH FACTOR REV., vol. 16, pages 233 - 247
ESWARAKUMAR ET AL., CYTOKINE GROWTH FACTOR REV., vol. 16, pages 139 - 149
OZAWA ET AL., TERATOG. CARCINOG. MUTAGEN., vol. 21, 2001, pages 27 - 44
DIECI ET AL., CANCER DISCOVERY, 2013, pages OF 1 - OF 16
WESCHE ET AL., BIOCHEM J, vol. 437, 2011, pages 199 - 213
S. MIURA ET AL., BMC CANCER, vol. 12, 2012, pages 1471 - 2407
BANGE ET AL., CANCER RES., vol. 62, 2002, pages 840 - 847
J. MED. CHEM., vol. 48, 2005, pages 4628 - 4653
Attorney, Agent or Firm:
HONESTY & JR PARTNERS INTELLECTUAL PROPERTY LAW GROUP (KR)
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