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Title:
NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2012/020742
Kind Code:
A1
Abstract:
Disclosed is a novel compound that acts as an antagonist for P2X3 and/or P2X2/3 receptors. Also disclosed is a pharmaceutical composition that acts as an antagonist for P2X3 and/or P2X2/3 receptors, said composition containing: a compound represented by formula (I), a pharmacologically permitted salt thereof, or a solvate of either. In the formula, ring A represents a substituted or unsubstituted five-to-seven-membered cycloalkane, a substituted or unsubstituted five-to-seven-membered cycloalkene, or the like; C represents a carbon atom; -X- represents -N(R16)- or the like; R16 represents hydrogen, a substituted or unsubstituted alkyl, or the like; R7 represents a substituted or unsubstituted five- or six-membered heteroaryl or a substituted or unsubstituted six-to-ten-membered aryl; each of Q1 and Q2 independently represents a carbon atom or a nitrogen atom; -L- represents -O-, -S-, or the like; R6 represents a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted cycloalkenyl, or the like; and R2 represents hydrogen, hydroxyl, or the like.

Inventors:
KAI HIROYUKI (JP)
ENDOH TAKESHI (JP)
MATSUMOTO SAE (JP)
ASAHI KENTARO (JP)
HORIGUCHI TOHRU (JP)
Application Number:
PCT/JP2011/068097
Publication Date:
February 16, 2012
Filing Date:
August 09, 2011
Export Citation:
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Assignee:
SHIONOGI & CO (JP)
KAI HIROYUKI (JP)
ENDOH TAKESHI (JP)
MATSUMOTO SAE (JP)
ASAHI KENTARO (JP)
HORIGUCHI TOHRU (JP)
International Classes:
A61K31/136; A61K31/415; A61K31/4168; A61K31/42; A61K31/421; A61K31/426; A61K31/4375; A61K31/44; A61K31/4412; A61K31/455; A61K31/47; A61K31/472; A61K31/4725; A61K31/4965; A61K31/502; A61K31/505; A61K31/506; A61K31/513; A61K31/517; A61K31/535; A61K31/536; A61K31/5377; A61K31/538; A61P13/10; A61P29/00; A61P43/00; C07C217/92; C07D213/74; C07D213/80; C07D213/82; C07D215/22; C07D217/24; C07D231/38; C07D233/96; C07D235/30; C07D237/32; C07D239/42; C07D239/47; C07D239/54; C07D239/84; C07D239/95; C07D239/96; C07D241/20; C07D255/02; C07D261/12; C07D263/32; C07D263/34; C07D263/48; C07D265/10; C07D265/26; C07D265/36; C07D277/20; C07D277/34; C07D277/38; C07D401/12; C07D405/12; C07D405/14; C07D417/12; C07D417/14
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Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
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