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Title:
NOVEL HISTAMINE LIBERATOR CONTAINED IN HUMAN SWEAT
Document Type and Number:
WIPO Patent Application WO/2014/003008
Kind Code:
A1
Abstract:
Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat from a sweat allergy patient in a dissolved state or a partial peptide of the protein.

Inventors:
HIDE MICHIHIRO (JP)
HIRAGUN TAKAAKI (JP)
ISHII KAORI (JP)
MIHARA SHOJI (JP)
HIRAGUN MAKIKO (JP)
SCHROEDER JENS-M (DE)
Application Number:
PCT/JP2013/067396
Publication Date:
January 03, 2014
Filing Date:
June 25, 2013
Export Citation:
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Assignee:
UNIV HIROSHIMA (JP)
International Classes:
C12N15/09; A61K9/70; A61K38/00; A61K39/395; A61P17/00; A61P37/08; C07K14/39; C07K16/14; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53; G01N33/543
Domestic Patent References:
WO2009133951A12009-11-05
WO2005005474A12005-01-20
WO2005005474A12005-01-20
WO2009133951A12009-11-05
Foreign References:
US6331415B12001-12-18
US5693761A1997-12-02
US5225539A1993-07-06
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US5612205A1997-03-18
US5814318A1998-09-29
US5545806A1996-08-13
US7145056B22006-12-05
US6492160B12002-12-10
US5871907A1999-02-16
US5733743A1998-03-31
JP3642340B22005-04-27
Other References:
DATABASE NUCLEOTIDE [online] 23 April 2008 (2008-04-23), XU, J. ET AL.: "Definition: Malassezia globosa CBS 7966 hypothetical protein MGL 1304 partial mRNA", XP055183506, retrieved from NCBI Database accession no. XM_001731984.1
RASOOL O. ET AL.: "Cloning, characterization and expression of complete coding sequences of three IgE binding Malassezia furfur allergens, Mal f 7, Mal f 8 and Mal f 9.", EUR.J.BIOCHEM., vol. 7, no. 14, 26 July 2000 (2000-07-26), pages 4355 - 4361, XP055183532
DATABASE NUCLEOTIDE [online] 8 March 2000 (2000-03-08), LINDBORG,M. ET AL.: "Definition: Malassezia furfur mRNA coding for potential allergen, strain ATCC no 42132", XP055190900, retrieved from NCBI Database accession no. AJ011958.1
DATABASE NUCLEOTIDE [online] 14 January 2002 (2002-01-14), LINDBORG,M. ET AL.: "Definition: Malassezia sympodialis mRNA for allergen Mal s 8, strain ATCC no 42132", XP055183544, retrieved from NCBI Database accession no. AJ011958.2
TOSHIO KANBE ET AL.: "Atopic Dermatitis and Malassezia Species : A Study of Antigenic Components of Malassezia Species for Immunoglobulin E of Patients with Atopic Dermatitis", JPN.J.MED.MYCOL., vol. 44, 2003, pages 71 - 75, XP055183552
SHINDO H. ET AL.: "Histamine release neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigens.", ARCH.DERMATOL.RES., vol. 304, no. 8, October 2012 (2012-10-01), pages 647 - 654, XP035114555
HIRAGUN T. ET AL.: "Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients.", J.ALLERGY CLIN.IMMUNOL.., 28 May 2013 (2013-05-28), XP055183565
KORO, O. ET AL., J. ALLERGY CLIN. IMMUNOL., vol. 103, 1999, pages 663 - 670
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 6, no. 5, 1996, pages 441 - 456
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY PRESS
KORO O ET AL., J. ALLERGY CLIN IMMUNOL, vol. 103, 1999, pages 663 - 670
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
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