Title:
NOVEL HUMAN PROTEIN KINASES AND PROTEIN KINASE-LIKE ENZYMES
Document Type and Number:
WIPO Patent Application WO2001038503
Kind Code:
A3
Abstract:
The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.
Inventors:
PLOWMAN GREGORY D (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
MARTINEZ RICARDO (US)
FLANAGAN PETER (US)
CLARY DOUGLAS (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
MARTINEZ RICARDO (US)
FLANAGAN PETER (US)
CLARY DOUGLAS (US)
Application Number:
PCT/US2000/032085
Publication Date:
January 31, 2002
Filing Date:
November 22, 2000
Export Citation:
Assignee:
SUGEN INC (US)
PLOWMAN GREGORY D (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
MARTINEZ RICARDO (US)
FLANAGAN PETER (US)
CLARY DOUGLAS (US)
PLOWMAN GREGORY D (US)
WHYTE DAVID (US)
MANNING GERARD (US)
SUDARSANAM SUCHA (US)
MARTINEZ RICARDO (US)
FLANAGAN PETER (US)
CLARY DOUGLAS (US)
International Classes:
C12N15/09; A61K38/00; A61P3/00; A61P9/00; A61P9/12; A61P15/10; A61P21/00; A61P25/00; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P27/02; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/00; A61P37/02; A61P43/00; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N9/99; C12Q1/48; C12Q1/68; C12R1/91; (IPC1-7): C07K14/47; A61K38/45; C07K16/40; C12N9/12
Domestic Patent References:
| WO1995007990A1 | 1995-03-23 | |||
| WO1994018328A1 | 1994-08-18 | |||
| WO2000017232A2 | 2000-03-30 | |||
| WO2000073469A2 | 2000-12-07 |
Foreign References:
| US6001623A | 1999-12-14 | |||
| US5747288A | 1998-05-05 |
Other References:
DI CUNTO FERDINANDO ET AL: "Citron Rho-interacting kinase, a novel tissue-specific Ser/Thr kinase encompassing the Rho-Rac-binding protein citron.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 45, 6 November 1998 (1998-11-06), pages 29706 - 29711, XP002170360, ISSN: 0021-9258
WEISS ELLEN R ET AL: "The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas.", MOLECULAR VISION, vol. 4, no. 27, 8 December 1998 (1998-12-08), pages NO PAGINATION, XP002177859, ISSN: 1090-0535
DATABASE EMBL EBI; 1 July 1997 (1997-07-01), NAGASE T. ET AL.: "Human mRNA for KIAA0303 gene, partial cds.", XP002177870
DATABASE EMBL EBI; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 19 clone CTD-2537I9", XP002177871
VERPLOEGEN SANDRA ET AL: "Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent kinase.", BLOOD, vol. 96, no. 9, 1 November 2000 (2000-11-01), pages 3215 - 3223, XP002177860, ISSN: 0006-4971
DATABASE EMBL EBI; 29 September 2000 (2000-09-29), SUGANO S. ET AL.: "Homo sapiens cDNA: FLJ23292 fis, clone HEP10334", XP002177872
TOKUMITSU HIROSHI ET AL: "Characterization of a Ca-2+/calmodulin-dependent protein kinase cascade: Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 33, 1995, pages 19320 - 19324, XP002177861, ISSN: 0021-9258
NAITO YASUHITO ET AL: "Isoform-specific activation and structural diversity of calmodulin kinase I.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 51, 19 December 1997 (1997-12-19), pages 32704 - 32708, XP002177862, ISSN: 0021-9258
HOCH BRIGITTE ET AL: "Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.", CIRCULATION RESEARCH, vol. 84, no. 6, 2 April 1999 (1999-04-02), pages 713 - 721, XP002177863, ISSN: 0009-7330
DATABASE EMBL EBI; 27 January 2000 (2000-01-27), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 5 clone CTD-2201J22", XP002177873
WANG Z-N ET AL: "Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet-treated rat adrenal", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 453, no. 1-2, 18 June 1999 (1999-06-18), pages 135 - 139, XP004259817, ISSN: 0014-5793
DATABASE EMBL EBI; 21 July 2000 (2000-07-21), LI Y. ET AL.: "Homo sapiens HSNFRK (HSNFRK) mRNA, complete cds", XP002177874
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. III. THE CODING SEQUENCES OF 40 NEW GENES (KIAA0081-KIAA0120) DEDUCED BY ANALYSIS OF CDNA CLONES FROM HUMAN CELL LINE KG-1", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 2, no. 1, 28 February 1995 (1995-02-28), pages 37 - 43, XP001011422, ISSN: 1340-2838
BECKER WALTER ET AL: "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases.", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 235, no. 3, 1996, pages 736 - 743, XP002177864, ISSN: 0014-2956
HERRING B P ET AL: "DOMAIN CHARACTERIZATION OF RABBIT SKELETAL MUSCLE MYOSIN LIGHT CHAIN KINASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 265, no. 3, 25 January 1990 (1990-01-25), pages 1724 - 1730, XP000979556, ISSN: 0021-9258
FISH KIMBERLY J ET AL: "Isolation and Characterization of Human Casein Kinase I-epsilon (CKI), a Novel Member of the CKI Gene Family.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 25, 1995, pages 14875 - 14883, XP002177865, ISSN: 0021-9258
DATABASE EBI EMBL; 3 March 2000 (2000-03-03), MIDMER M., HAQ R., ZANKE B.W.: "NKIAMRE a novel kinase deleted in human leukemia", XP002177875
DATABASE EBI EMBL; 28 October 1998 (1998-10-28), HILLIER L. ET AL.: "WashU-NCI human EST Project", XP002177876
ABE M K ET AL: "EXTRACELLULAR SIGNAL-REGULATED KINASE 7 (ERK7), A NOVEL ERK WITH A C-TERMINAL DOMAIN THAT REGULATES ITS ACTIVITY, ITS CELLULAR LOCALIZATION, AND CELL GROWTH", MOLECULAR AND CELLULAR BIOLOGY, WASHINGTON, DC, US, vol. 19, no. 2, February 1999 (1999-02-01), pages 1301 - 1312, XP002172155, ISSN: 0270-7306
DATABASE EMBL EBI; 13 September 1999 (1999-09-13), NCI-CGAP: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP)", XP002177877
DATABASE EMBL EBI; 15 March 1999 (1999-03-15), MEI G. ET AL.: "Homo sapiens clone 25110 mRNA sequence, full-length", XP002177878
ANAYA P ET AL: "Isolation of the Aspergillus nidulans sudD gene and its human homologue", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 211, no. 2, 12 May 1998 (1998-05-12), pages 323 - 329, XP004120595, ISSN: 0378-1119
TANAKA HIROMITSU ET AL: "Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 17049 - 17057, XP002177866, ISSN: 0021-9258
DATABASE EMBL EBI; 6 October 1999 (1999-10-06), BIRREN B., LINTON L., NUSBAUM C., LANDER E.: "Homo sapiens chromosome 17 clone RP11-231G16", XP002177879
DATABASE EMBL EBI; 17 September 1999 (1999-09-17), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 19 clone CTC-492K19", XP002177880
MAUCUER A ET AL: "KIS is a protein kinase with an RNA recognition motif", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23151 - 23156, XP002125937, ISSN: 0021-9258
BATTELLE BARBARA-ANNE ET AL: "A myosin III from Limulus eyes is a clock-regulated phosphoprotein.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 12, 15 June 1998 (1998-06-15), pages 4548 - 4559, XP002177867, ISSN: 0270-6474
BIELKE W ET AL: "Characterization of a novel murine testis-specific serine/threonine kinase", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 139, no. 2, 1994, pages 235 - 239, XP002174517, ISSN: 0378-1119
DATABASE EMBL EBI; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 5 clone CTC-380F16", XP002177881
DATABASE EMBL EBI; 8 January 1999 (1999-01-08), NARA K.: "Cloning and characterization of a novel serine/threonine protein kinase gene expressed dominatly in developing brain", XP002177882
DATABASE EMBL EBI; 4 August 1998 (1998-08-04), LEWIS S., WANG Y., ROE B.A.: "Homo sapiens Chromosome 22q11.2 Cosmid Clone cosi In NF1 Region", XP002177883
ZHENG CHAO-FENG ET AL: "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 15, 1993, pages 11435 - 11439, XP002177868, ISSN: 0021-9258
DATABASE EMBL EBI; 6 October 1999 (1999-10-06), KAUL R.K. ET AL.: "Homo sapiens chromosome 7 clone RP11-286H14", XP002177884
PARK S ET AL: "THE EEK RECEPTOR, A MEMBER OF THE EPH FAMILY OF TYROSINE PROTEIN KINASES, CAN BE ACTIVATED BY THREE DIFFERENT EPH FAMILY LIGANDS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 14, no. 5, 6 February 1997 (1997-02-06), pages 533 - 542, XP001009718, ISSN: 0950-9232
KLAUCK THERESA M ET AL: "Cloning and characterization of a glucocorticoid-induced diacylglycerol kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 33, 1996, pages 19781 - 19788, XP002177869, ISSN: 0021-9258
WEISS ELLEN R ET AL: "The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas.", MOLECULAR VISION, vol. 4, no. 27, 8 December 1998 (1998-12-08), pages NO PAGINATION, XP002177859, ISSN: 1090-0535
DATABASE EMBL EBI; 1 July 1997 (1997-07-01), NAGASE T. ET AL.: "Human mRNA for KIAA0303 gene, partial cds.", XP002177870
DATABASE EMBL EBI; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 19 clone CTD-2537I9", XP002177871
VERPLOEGEN SANDRA ET AL: "Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent kinase.", BLOOD, vol. 96, no. 9, 1 November 2000 (2000-11-01), pages 3215 - 3223, XP002177860, ISSN: 0006-4971
DATABASE EMBL EBI; 29 September 2000 (2000-09-29), SUGANO S. ET AL.: "Homo sapiens cDNA: FLJ23292 fis, clone HEP10334", XP002177872
TOKUMITSU HIROSHI ET AL: "Characterization of a Ca-2+/calmodulin-dependent protein kinase cascade: Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 33, 1995, pages 19320 - 19324, XP002177861, ISSN: 0021-9258
NAITO YASUHITO ET AL: "Isoform-specific activation and structural diversity of calmodulin kinase I.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 51, 19 December 1997 (1997-12-19), pages 32704 - 32708, XP002177862, ISSN: 0021-9258
HOCH BRIGITTE ET AL: "Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.", CIRCULATION RESEARCH, vol. 84, no. 6, 2 April 1999 (1999-04-02), pages 713 - 721, XP002177863, ISSN: 0009-7330
DATABASE EMBL EBI; 27 January 2000 (2000-01-27), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 5 clone CTD-2201J22", XP002177873
WANG Z-N ET AL: "Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet-treated rat adrenal", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 453, no. 1-2, 18 June 1999 (1999-06-18), pages 135 - 139, XP004259817, ISSN: 0014-5793
DATABASE EMBL EBI; 21 July 2000 (2000-07-21), LI Y. ET AL.: "Homo sapiens HSNFRK (HSNFRK) mRNA, complete cds", XP002177874
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. III. THE CODING SEQUENCES OF 40 NEW GENES (KIAA0081-KIAA0120) DEDUCED BY ANALYSIS OF CDNA CLONES FROM HUMAN CELL LINE KG-1", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 2, no. 1, 28 February 1995 (1995-02-28), pages 37 - 43, XP001011422, ISSN: 1340-2838
BECKER WALTER ET AL: "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases.", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 235, no. 3, 1996, pages 736 - 743, XP002177864, ISSN: 0014-2956
HERRING B P ET AL: "DOMAIN CHARACTERIZATION OF RABBIT SKELETAL MUSCLE MYOSIN LIGHT CHAIN KINASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 265, no. 3, 25 January 1990 (1990-01-25), pages 1724 - 1730, XP000979556, ISSN: 0021-9258
FISH KIMBERLY J ET AL: "Isolation and Characterization of Human Casein Kinase I-epsilon (CKI), a Novel Member of the CKI Gene Family.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 25, 1995, pages 14875 - 14883, XP002177865, ISSN: 0021-9258
DATABASE EBI EMBL; 3 March 2000 (2000-03-03), MIDMER M., HAQ R., ZANKE B.W.: "NKIAMRE a novel kinase deleted in human leukemia", XP002177875
DATABASE EBI EMBL; 28 October 1998 (1998-10-28), HILLIER L. ET AL.: "WashU-NCI human EST Project", XP002177876
ABE M K ET AL: "EXTRACELLULAR SIGNAL-REGULATED KINASE 7 (ERK7), A NOVEL ERK WITH A C-TERMINAL DOMAIN THAT REGULATES ITS ACTIVITY, ITS CELLULAR LOCALIZATION, AND CELL GROWTH", MOLECULAR AND CELLULAR BIOLOGY, WASHINGTON, DC, US, vol. 19, no. 2, February 1999 (1999-02-01), pages 1301 - 1312, XP002172155, ISSN: 0270-7306
DATABASE EMBL EBI; 13 September 1999 (1999-09-13), NCI-CGAP: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP)", XP002177877
DATABASE EMBL EBI; 15 March 1999 (1999-03-15), MEI G. ET AL.: "Homo sapiens clone 25110 mRNA sequence, full-length", XP002177878
ANAYA P ET AL: "Isolation of the Aspergillus nidulans sudD gene and its human homologue", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 211, no. 2, 12 May 1998 (1998-05-12), pages 323 - 329, XP004120595, ISSN: 0378-1119
TANAKA HIROMITSU ET AL: "Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 17049 - 17057, XP002177866, ISSN: 0021-9258
DATABASE EMBL EBI; 6 October 1999 (1999-10-06), BIRREN B., LINTON L., NUSBAUM C., LANDER E.: "Homo sapiens chromosome 17 clone RP11-231G16", XP002177879
DATABASE EMBL EBI; 17 September 1999 (1999-09-17), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 19 clone CTC-492K19", XP002177880
MAUCUER A ET AL: "KIS is a protein kinase with an RNA recognition motif", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23151 - 23156, XP002125937, ISSN: 0021-9258
BATTELLE BARBARA-ANNE ET AL: "A myosin III from Limulus eyes is a clock-regulated phosphoprotein.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 12, 15 June 1998 (1998-06-15), pages 4548 - 4559, XP002177867, ISSN: 0270-6474
BIELKE W ET AL: "Characterization of a novel murine testis-specific serine/threonine kinase", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 139, no. 2, 1994, pages 235 - 239, XP002174517, ISSN: 0378-1119
DATABASE EMBL EBI; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 5 clone CTC-380F16", XP002177881
DATABASE EMBL EBI; 8 January 1999 (1999-01-08), NARA K.: "Cloning and characterization of a novel serine/threonine protein kinase gene expressed dominatly in developing brain", XP002177882
DATABASE EMBL EBI; 4 August 1998 (1998-08-04), LEWIS S., WANG Y., ROE B.A.: "Homo sapiens Chromosome 22q11.2 Cosmid Clone cosi In NF1 Region", XP002177883
ZHENG CHAO-FENG ET AL: "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 15, 1993, pages 11435 - 11439, XP002177868, ISSN: 0021-9258
DATABASE EMBL EBI; 6 October 1999 (1999-10-06), KAUL R.K. ET AL.: "Homo sapiens chromosome 7 clone RP11-286H14", XP002177884
PARK S ET AL: "THE EEK RECEPTOR, A MEMBER OF THE EPH FAMILY OF TYROSINE PROTEIN KINASES, CAN BE ACTIVATED BY THREE DIFFERENT EPH FAMILY LIGANDS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 14, no. 5, 6 February 1997 (1997-02-06), pages 533 - 542, XP001009718, ISSN: 0950-9232
KLAUCK THERESA M ET AL: "Cloning and characterization of a glucocorticoid-induced diacylglycerol kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 33, 1996, pages 19781 - 19788, XP002177869, ISSN: 0021-9258
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