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Title:
NOVEL HYDROXAMIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/132712
Kind Code:
A1
Abstract:
Provided is a novel compound that is useful as a medical drug in that said compound displays strong antimicrobial activity against gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant strains thereof, on the basis of LpxC-inhibiting activity. The novel compound is a hydroxamic acid derivative represented by general formula 1 (1) or a pharmaceutically acceptable salt thereof.

Inventors:
TAKASHIMA, Hajime (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
高島 一 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
TSURUTA, Risa (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
鶴田 理紗 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
YABUUCHI, Tetsuya (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
薮内 哲也 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
OKA, Yusuke (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
岡 裕輔 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
URABE, Hiroki (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
浦部 洋樹 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
SUGA, Yoichiro (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
Application Number:
JP2011/059737
Publication Date:
October 27, 2011
Filing Date:
April 20, 2011
Export Citation:
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Assignee:
TAISHO PHARMACEUTICAL CO., LTD. (24-1, Takada 3-chome Toshima-k, Tokyo 33, 〒1708633, JP)
大正製薬株式会社 (〒33 東京都豊島区高田3丁目24番1号 Tokyo, 〒1708633, JP)
TOYAMA CHEMICAL CO., LTD. (2-5 Nishishinjuku 3-chome, Shinjuku-ku Tokyo, 23, 〒1600023, JP)
富山化学工業株式会社 (〒23 東京都新宿区西新宿三丁目2番5号 Tokyo, 〒1600023, JP)
TAKASHIMA, Hajime (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
高島 一 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
TSURUTA, Risa (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
鶴田 理紗 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
YABUUCHI, Tetsuya (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
薮内 哲也 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
OKA, Yusuke (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
岡 裕輔 (〒33 東京都豊島区高田3丁目24番1号 大正製薬株式会社内 Tokyo, 〒1708633, JP)
URABE, Hiroki (24-1, Takada 3-chome, Toshima-k, Tokyo 33, 〒1708633, JP)
International Classes:
C07C259/06; A61K31/166; A61K31/337; A61K31/341; A61K31/343; A61K31/351; A61K31/357; A61K31/36; A61K31/381; A61K31/397; A61K31/40; A61K31/4015; A61K31/402; A61K31/403; A61K31/4035; A61K31/404; A61K31/4045; A61K31/407; A61K31/415; A61K31/416; A61K31/4164; A61K31/4184; A61K31/42; A61K31/421; A61K31/422; A61K31/4245; A61K31/426; A61K31/428; A61K31/433; A61K31/437; A61K31/438; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/4453; A61K31/47; A61K31/496; A61K31/5375; A61K31/5377; A61K31/538; A61K31/5386; A61K31/54; A61K31/553; A61P31/04; A61P43/00; C07C323/62; C07D205/04; C07D205/12; C07D207/10; C07D207/12; C07D207/27; C07D207/327; C07D209/08; C07D209/12; C07D209/14; C07D209/44; C07D209/52; C07D211/14; C07D211/18; C07D211/38; C07D211/46; C07D211/56; C07D211/70; C07D213/38; C07D213/40; C07D213/54; C07D213/61; C07D213/64; C07D213/65; C07D213/70; C07D213/74; C07D213/81; C07D215/14; C07D217/04; C07D217/12; C07D231/12; C07D231/56; C07D233/61; C07D235/04; C07D257/04; C07D261/08; C07D263/14; C07D263/32; C07D263/56; C07D265/30; C07D265/38; C07D267/10; C07D271/12; C07D277/20; C07D277/30; C07D277/62; C07D277/66; C07D285/12; C07D295/08; C07D295/12; C07D295/14; C07D295/16; C07D305/06; C07D305/08; C07D307/14; C07D307/18; C07D307/52; C07D307/54; C07D307/78; C07D307/82; C07D307/87; C07D309/04; C07D309/14; C07D317/30; C07D317/60; C07D319/18; C07D319/20; C07D333/24; C07D405/06; C07D413/06; C07D471/04; C07D471/10; C07D487/08; C07D491/20; C07D498/08
Domestic Patent References:
WO2000059874A12000-10-12
WO2008154642A22008-12-18
WO2010031750A12010-03-25
WO2002030873A12002-04-18
WO2008045671A12008-04-17
WO2004058728A12004-07-15
WO2004062601A22004-07-29
WO2007069020A22007-06-21
WO2008154642A22008-12-18
WO2010031750A12010-03-25
WO2010017060A12010-02-11
WO2010032147A22010-03-25
WO2009007814A12009-01-15
Foreign References:
US20070066646A12007-03-22
JP2006519772A2006-08-31
US20100135960A12010-06-03
Other References:
See also references of EP 2562155A4
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Attorney, Agent or Firm:
ONO, Shinjiro et al. (YUASA AND HARA, Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, 〒1000004, JP)
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Claims: