Title:
NOVEL IMIDAZOLE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/172871
Kind Code:
A1
Abstract:
The present invention relates to: a novel imidazole derivative compound; an isomer thereof or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition comprising same. An imidazole derivative compound according to the present invention exhibits selective inhibitory activity against JNK, particularly JNK3, and thus can be used as a pharmaceutical composition for preventing and treating degenerative brain diseases (degenerative brain diseases including Alzheimer's dementia, and Parkinson's disease).
Inventors:
HAH JUNG MI (KR)
JANG MI YOUNG (KR)
JANG MI YOUNG (KR)
Application Number:
PCT/KR2021/002321
Publication Date:
September 02, 2021
Filing Date:
February 24, 2021
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C07D487/04; A61K31/506; A61P25/16; A61P25/28
Domestic Patent References:
| WO2010069833A1 | 2010-06-24 |
Foreign References:
| KR20200011388A | 2020-02-03 | |||
| KR101840674B1 | 2018-03-21 | |||
| US8569306B2 | 2013-10-29 |
Other References:
JANG MIYOUNG, OH YOURI, CHO HYUNWOOK, YANG SONGYI, MOON HYUNGWOO, IM DASEUL, HAH JUNG-MI: "Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1H)-Carboxamide as a Novel JNK Inhibitor", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. art. 1698, 2 March 2020 (2020-03-02), pages 1 - 17, XP055841230, DOI: 10.3390/ijms21051698
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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