Title:
NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE
Document Type and Number:
WIPO Patent Application WO/2017/007008
Kind Code:
A1
Abstract:
Provided are novel low-molecular-weight compounds for suppressing the inductive production of MMPs, especially MMP-9, rather than the constitutive production of MMP-2. The present invention pertains to compounds represented by formula (I): (each of the symbols in the formula is as described in the specification). These compounds have a selective inhibitory effect on MMP-9 production, and are useful as agents for the prevention and/or treatment of rheumatoid arthritis and other autoimmune diseases, inflammatory bowel diseases (ulcerative colitis, Crohn's disease), and osteoarthritis.
Inventors:
ISHIBUCHI SEIGO (JP)
SARUTA KUNIO (JP)
HAMADA MAIKO (JP)
MATOBA NOBUATSU (JP)
MATSUDAIRA TETSUJI (JP)
SEKI MAKI (JP)
TARAO AKIKO (JP)
HONJO TAKASHI (JP)
OGATA SHINGO (JP)
KAWATA ATSUSHI (JP)
MOROKUMA KENJI (JP)
FUJIE NAOTO (JP)
AOYAMA YUKIO (JP)
SARUTA KUNIO (JP)
HAMADA MAIKO (JP)
MATOBA NOBUATSU (JP)
MATSUDAIRA TETSUJI (JP)
SEKI MAKI (JP)
TARAO AKIKO (JP)
HONJO TAKASHI (JP)
OGATA SHINGO (JP)
KAWATA ATSUSHI (JP)
MOROKUMA KENJI (JP)
FUJIE NAOTO (JP)
AOYAMA YUKIO (JP)
Application Number:
PCT/JP2016/070214
Publication Date:
January 12, 2017
Filing Date:
July 08, 2016
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
C07D233/78; A61K31/4178; A61K31/437; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61K31/497; A61K31/501; A61P1/04; A61P19/02; A61P25/00; A61P29/00; A61P37/06; A61P43/00; C07D401/10; C07D401/12; C07D401/14; C07D403/10; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D498/04; C07D513/04
Domestic Patent References:
| WO2011136292A1 | 2011-11-03 | |||
| WO2004033632A2 | 2004-04-22 |
Foreign References:
| JP2008505172A | 2008-02-21 | |||
| JP2008524211A | 2008-07-10 |
Other References:
DUAN, J. J.-W. ET AL.: "Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-a converting enzyme", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, no. 12, 2005, pages 2970 - 2973, XP027801660, ISSN: 0960-894X
See also references of EP 3321256A4
See also references of EP 3321256A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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