Title:
NOVEL INDOLOQUINAZOLINE COMPOUND AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2018/123467
Kind Code:
A1
Abstract:
An indoloquinazoline compound represented by a specific structure. Clones having exceptional AI activity were detected by metagenomic analysis, and a novel indoloquinazoline compound synthase was identified from the clones. The novel indoloquinazoline compound has high resistance to decomposition by microorganisms and has AI activity. The novel indoloquinazoline compound can be used to control the QS mechanism in the fermentation field. This compound can be synthesized biologically and chemically.
Inventors:
KIMURA NOBUTADA (JP)
FUJITA MASAKI (JP)
FUJITA MASAKI (JP)
Application Number:
PCT/JP2017/043634
Publication Date:
July 05, 2018
Filing Date:
December 05, 2017
Export Citation:
Assignee:
AIST (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C12P17/18; C07D487/04; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N15/09
Foreign References:
| JP2009095284A | 2009-05-07 |
Other References:
KIMURA, N. ET AL.: "Isolation and characterization of a 4-nitrotoluene-oxidizing enzyme from activated sludge by a metagenomic approach", MICROBES AND ENVIRONMENTS, vol. 25, no. 2, 2010, pages 133 - 139, XP055462422
JAO, C. W. ET AL.: "Isolation, structure elucidation, and synthesis of cytotoxic tryptanthrin analogues from Phaius mishmensis", JOURNAL OF NATURAL PRODUCTS, vol. 71, no. 7, July 2008 (2008-07-01), pages 1275 - 1279, XP055516799
JAO, C. W. ET AL.: "Isolation, structure elucidation, and synthesis of cytotoxic tryptanthrin analogues from Phaius mishmensis", JOURNAL OF NATURAL PRODUCTS, vol. 71, no. 7, July 2008 (2008-07-01), pages 1275 - 1279, XP055516799
Attorney, Agent or Firm:
KIMURA Mitsuru (JP)
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