Title:
NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
Document Type and Number:
WIPO Patent Application WO/2014/079995
Kind Code:
A3
Abstract:
The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders wherein Y1 and Y2 are adjacent atoms in Het1, which are independently selected from the group consisting of carbon and nitrogen; k is 0, 1, 2 or 3; Het1 is a bivalent monocyclic 5- or 6-membered heteroaromatic radical, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N-Ra as ring members, or a bivalent fused bicyclic 8-, 9- or 10-membered heteroaromatic radical, having 1, 2, 3 or 4 heteroatoms or heteroatom moieties selected from O, S, N and N-Ra as ring members; Het2 is inter alia monocyclic 5- or 6-membered hetaryl, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N-R1a as ring members, Cyc is inter alia optionally substituted monocyclic 5- or 6-membered hetaryl or optionally substituted fused 8-, 9- or 10-membered bicyclic hetaryl; Ar is optionally substituted phenylene or optionally substituted bivalent 6-membered hetaryl; R is attached to a carbon atom of Het1 and inter alia - halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-fluoroalkyl, C1-C6-fluoroalkoxy, C3-C6-cycloalkyl etc.
Inventors:
GENESTE HERVÉ (DE)
TURNER SEAN (DE)
OCHSE MICHAEL (DE)
DRESCHER KARLA (DE)
BLACK LAWRENCE A (US)
JANTOS KATJA (DE)
JACOBS CLARISSA (DE)
TURNER SEAN (DE)
OCHSE MICHAEL (DE)
DRESCHER KARLA (DE)
BLACK LAWRENCE A (US)
JANTOS KATJA (DE)
JACOBS CLARISSA (DE)
Application Number:
PCT/EP2013/074532
Publication Date:
July 17, 2014
Filing Date:
November 25, 2013
Export Citation:
Assignee:
ABBVIE INC (US)
ABBVIE DEUTSCHLAND (DE)
ABBVIE DEUTSCHLAND (DE)
International Classes:
C07D401/14; A61K31/4353; A61K31/4427; C07D401/04; C07D401/10; C07D471/04; C07D487/04; A61P25/00
Domestic Patent References:
| WO2012064603A1 | 2012-05-18 | |||
| WO2011072694A1 | 2011-06-23 |
Foreign References:
| US20130158031A1 | 2013-06-20 | |||
| US20070155779A1 | 2007-07-05 |
Attorney, Agent or Firm:
REITSTÖTTER - KINZEBACH (Ludwigshafen, DE)
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