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Title:
NOVEL IODOBENZYL-BLEOMYCIN COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/096374
Kind Code:
A1
Abstract:
Provided is a novel iodobenzyl-bleomycin compound. Also provided are metal complexes that consist of the iodobenzyl-bleomycin compound and various metal atoms, such as an iodobenzyl-Co-bleomycin compound, that can accumulate on malignant tumors, and that have improved biological characteristics in terms of accumulability on malignant tumors compared to conventional compounds. Also provided are methods for synthesizing the iodobenzyl-bleomycin compound and the metal complexes of the iodobenzyl-bleomycin compound and various metal atoms. The novel iodobenzyl-bleomycin compound is synthesized by adding, to a terminal amino group of bleomycin, iodobenzyl iodide synthesized by using iodobenzyl alcohol and iodine as starting materials.

Inventors:
ANDO, Atsushi (National University Corporation Okayama University 5-1, Shikata-cho 2-chome, Kita-ku, Okayama-sh, Okayama 58, 〒7008558, JP)
安東 醇 (〒58 岡山県岡山市北区鹿田町二丁目5番1号 国立大学法人岡山大学医学部内 Okayama, 〒7008558, JP)
ANDO, Itsuko (National University Corporation Okayama University 5-1, Shikata-cho 2-chome, Kita-ku, Okayama-sh, Okayama 58, 〒7008558, JP)
安東 逸子 (〒58 岡山県岡山市北区鹿田町二丁目5番1号 国立大学法人岡山大学医学部内 Okayama, 〒7008558, JP)
Application Number:
JP2011/051974
Publication Date:
August 11, 2011
Filing Date:
February 01, 2011
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (1-1 Tsushima-Naka 1-chome, Kita-ku Okayama-sh, Okayama 30, 〒7008530, JP)
国立大学法人 岡山大学 (〒30 岡山県岡山市北区津島中一丁目1番1号 Okayama, 〒7008530, JP)
ANDO, Atsushi (National University Corporation Okayama University 5-1, Shikata-cho 2-chome, Kita-ku, Okayama-sh, Okayama 58, 〒7008558, JP)
安東 醇 (〒58 岡山県岡山市北区鹿田町二丁目5番1号 国立大学法人岡山大学医学部内 Okayama, 〒7008558, JP)
ANDO, Itsuko (National University Corporation Okayama University 5-1, Shikata-cho 2-chome, Kita-ku, Okayama-sh, Okayama 58, 〒7008558, JP)
International Classes:
C07H15/26; A61K31/7064; A61K38/00; A61K51/00; A61P35/00; C07B59/00; G01N33/48; C07F15/06
Foreign References:
US4758421A
US5420228A
US4933157A
JP2006232843A
Other References:
C. M. VOS ET AL. INTERNATIONAL JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY vol. 9, no. 4, 1982, pages 237 - 243
LESLIE H. DERIEMER ET AL. JOURNAL OF MEDICINAL CHEMISTRY vol. 22, no. 9, 1979, pages 1019 - 1023
C. M. VOS ET AL. EUROPEAN JOURNAL OF NUCLEAR MEDICINE vol. 7, no. 2, 1982, pages 92 - 94
JUNICHI KAKINUMA ET AL. JAPANESE JOURNAL OF NUCLEAR MEDICINE vol. 18, no. 6, 1981, pages 835 - 839
ALAN A. WILSON ET AL. JOURNAL OF MEDICINAL CHEMISTRY vol. 32, no. 5, 1989, pages 1057 - 1062
S. M. N. EFANGE ET AL. NUCLEAR MEDICINE AND BIOLOGY vol. 22, no. 4, 1995, pages 437 - 444
SRIRAM SHANKAR ET AL. BIOORGANIC & MEDICINAL CHEMISTRY vol. 13, no. 12, 2005, pages 3889 - 3898
Attorney, Agent or Firm:
SHOJI, Takashi et al. (6F 3-4-1, Higashi-nihonbashi Chuo-k, Tokyo 04, 〒1030004, JP)
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Claims: