Title:
NOVEL ISOMERIC COMPOUNDS COMPRISING A RING-OPENED THIOSUCCINIMIDE GROUP, AN OLIGOPEPTIDE FRAGMENT AND A CHIRAL MOIETY
Document Type and Number:
WIPO Patent Application WO/2022/133772
Kind Code:
A1
Abstract:
It relates to the medicinal chemistry field, particularly to a process for separating the isomeric compounds comprising a ring-opened thiosuccinimide group and a chiral moiety.
Inventors:
QIN GANG (CN)
LIU CHONG (CN)
HU LEHUA (CN)
LIU CHONG (CN)
HU LEHUA (CN)
Application Number:
PCT/CN2020/138509
Publication Date:
June 30, 2022
Filing Date:
December 23, 2020
Export Citation:
Assignee:
GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN)
International Classes:
A61K31/537; A61K39/00; A61K45/00; A61P35/00; B01D15/08; C07B57/00; C07K1/22; C07K16/28; C07K16/32
Domestic Patent References:
| WO2016207103A1 | 2016-12-29 | |||
| WO2016207089A1 | 2016-12-29 | |||
| WO2016207104A1 | 2016-12-29 | |||
| WO2016207094A1 | 2016-12-29 |
Foreign References:
| US20170112944A1 | 2017-04-27 |
Other References:
BEN-QUAN SHEN, KEYANG XU, LUNA LIU, HELGA RAAB, SUNIL BHAKTA, MARGARET KENRICK, KATHRYN L PARSONS-REPONTE, JANET TIEN, SHANG-FAN Y: "Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates", NATURE BIOTECHNOLOGY, vol. 30, no. 2, pages 184 - 189, XP055123129, ISSN: 1087-0156, DOI: 10.1038/nbt.2108
JOSE F. PONTE, XIUXIA SUN, NICHOLAS C. YODER, NATHAN FISHKIN, RASSOL LALEAU, JENNIFER COCCIA, LEANNE LANIERI, MEGAN BOGALHAS, LINT: "Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody–Maytansinoid Conjugates", BIOCONJUGATE CHEMISTRY, vol. 27, no. 7, 20 July 2016 (2016-07-20), US , pages 1588 - 1598, XP055418243, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00117
JOSE F. PONTE, XIUXIA SUN, NICHOLAS C. YODER, NATHAN FISHKIN, RASSOL LALEAU, JENNIFER COCCIA, LEANNE LANIERI, MEGAN BOGALHAS, LINT: "Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody–Maytansinoid Conjugates", BIOCONJUGATE CHEMISTRY, vol. 27, no. 7, 20 July 2016 (2016-07-20), US , pages 1588 - 1598, XP055418243, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00117
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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