Title:
NOVEL ISOQUINOLINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/005648
Kind Code:
A1
Abstract:
Novel isoquinoline derivatives represented by general formula (I) or pharmaceutically acceptable acid-addition salts thereof, prepared by aiming at providing novel compounds which have an inhibitory activity on nerve cell death of the apoptosis type, wherein Ar represents an optionally substituted aromatic ring; and n is 0, 1 or 2. Because of the inhibitory effect on cell death, these compounds are useful as preventives and remedies for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, ischemic cerebral diseases such as cerebral stroke, and peripheral nerve disorders observed in diabetes, etc.
Inventors:
ISHIGURO SUSUMU (JP)
SHIMADA SHINICHI (JP)
SEYA MOTOHIDE (JP)
OKUE MASAYUKI (JP)
YAGI YUZO (JP)
OGANE NOBUO (JP)
SAITOU YASUNARI (JP)
SHIMADA SHINICHI (JP)
SEYA MOTOHIDE (JP)
OKUE MASAYUKI (JP)
YAGI YUZO (JP)
OGANE NOBUO (JP)
SAITOU YASUNARI (JP)
Application Number:
PCT/JP1997/002765
Publication Date:
February 12, 1998
Filing Date:
August 07, 1997
Export Citation:
Assignee:
SNOW BRAND MILK PRODUCTS CO LTD (JP)
ISHIGURO SUSUMU (JP)
SHIMADA SHINICHI (JP)
SEYA MOTOHIDE (JP)
OKUE MASAYUKI (JP)
YAGI YUZO (JP)
OGANE NOBUO (JP)
SAITO YASUNARI (JP)
ISHIGURO SUSUMU (JP)
SHIMADA SHINICHI (JP)
SEYA MOTOHIDE (JP)
OKUE MASAYUKI (JP)
YAGI YUZO (JP)
OGANE NOBUO (JP)
SAITO YASUNARI (JP)
International Classes:
A61K31/47; A61K31/472; A61K31/495; A61K31/505; A61P9/00; A61P9/10; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; C07D217/02; C07D401/12; C07D413/12; C07D417/12; C07D521/00; (IPC1-7): C07D217/02; C07D401/12; C07D413/12; C07D417/12
Foreign References:
| JPH06507643A | 1994-09-01 | |||
| JPS5036470A | 1975-04-05 |
Other References:
See also references of EP 0855391A4
Attorney, Agent or Firm:
Funahashi, Eiko (3rd floor 16-4, Nishishinbashi 1-chom, Minato-ku Tokyo 105, JP)
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