Title:
NOVEL K04-0144 SUBSTANCES AND PROCESS FOR PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/132537
Kind Code:
A1
Abstract:
K04-0144 substances A, B and C which can be produced by culturing a microorganism exemplified by Streptomyces sp. strain K04-0144 (which is capable of producing K04-0144 substances) in a culture medium and then collecting the substances from the culture medium. The substances have a potent antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and are therefore useful as therapeutic agents for MRSA infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria. A novel K04-0144 substance D which is also collected from the culture medium can enhance the effect of a β-lactam antibiotic (which has been used as an antibacterial agent) by using it in combination with the β-lactam antibiotic, and is therefore useful as a therapeutic agent for methicillin-resistant Staphylococcus aureus (MRSA) infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria.
Inventors:
TOMODA HIROSHI (JP)
KIM YONG-PIL (JP)
HANAKI HIDEAKI (JP)
MATSUMOTO ATSUKO (JP)
TAKAHASHI YOKO (JP)
OMURA SATOSHI (JP)
KIM YONG-PIL (JP)
HANAKI HIDEAKI (JP)
MATSUMOTO ATSUKO (JP)
TAKAHASHI YOKO (JP)
OMURA SATOSHI (JP)
Application Number:
PCT/JP2006/310091
Publication Date:
November 22, 2007
Filing Date:
May 16, 2006
Export Citation:
Assignee:
KITASATO INST (JP)
TOMODA HIROSHI (JP)
KIM YONG-PIL (JP)
HANAKI HIDEAKI (JP)
MATSUMOTO ATSUKO (JP)
TAKAHASHI YOKO (JP)
OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
KIM YONG-PIL (JP)
HANAKI HIDEAKI (JP)
MATSUMOTO ATSUKO (JP)
TAKAHASHI YOKO (JP)
OMURA SATOSHI (JP)
International Classes:
C12P19/26; A61K31/7024; A61P31/04; C07H11/04
Foreign References:
| JPH09509677A | 1997-09-30 | |||
| JP2006305625W | 2006-03-15 |
Other References:
DONNERSTAG A. ET AL.: "A structurally and biogenetically interesting moenomycin antibiotic", TETRAHEDRON, vol. 51, no. 7, 1995, pages 1931 - 1940, XP004104826
See also references of EP 2019147A4
HIROMI HASEGAWA ET AL., SCIENCE OF ANTIBIOTIC ADMINISTRATION, 1998, pages 264 - 273
E.B. SHIRLING; D. GOTTLIEB, INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 16, 1966, pages 313
"Color Harmony Manual", 1958, CONTAINER CORP. OF AMERICA
BERGEY'S MANUAL OF SYSTEMATIC BACTERIOLOGY, vol. 4, 1989
1-5-8 KAZUSA-KAMATARI; KISARAZU-SHI; CHIBA-KEN: "Purposes of Patent Procedure in the International Administrative Agency", NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION PATENT MICROORGANISMS DEPOSITARY (NPMD, 30 June 2005 (2005-06-30), pages 292 - 0818
"Method of Japan Society of Chemotherapy", CHEMOTHERAPY, vol. 29, 1981, pages 76 - 79
KAITO ET AL., MICROBIAL PATHOGENESIS, vol. 32, 2002, pages 183 - 190
"Japan Society of Chemotherapy", CHEMOTHERAPY, vol. 38, 1990, pages 103 - 105
See also references of EP 2019147A4
HIROMI HASEGAWA ET AL., SCIENCE OF ANTIBIOTIC ADMINISTRATION, 1998, pages 264 - 273
E.B. SHIRLING; D. GOTTLIEB, INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 16, 1966, pages 313
"Color Harmony Manual", 1958, CONTAINER CORP. OF AMERICA
BERGEY'S MANUAL OF SYSTEMATIC BACTERIOLOGY, vol. 4, 1989
1-5-8 KAZUSA-KAMATARI; KISARAZU-SHI; CHIBA-KEN: "Purposes of Patent Procedure in the International Administrative Agency", NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION PATENT MICROORGANISMS DEPOSITARY (NPMD, 30 June 2005 (2005-06-30), pages 292 - 0818
"Method of Japan Society of Chemotherapy", CHEMOTHERAPY, vol. 29, 1981, pages 76 - 79
KAITO ET AL., MICROBIAL PATHOGENESIS, vol. 32, 2002, pages 183 - 190
"Japan Society of Chemotherapy", CHEMOTHERAPY, vol. 38, 1990, pages 103 - 105
Attorney, Agent or Firm:
KOBAYASHI, Kazunori (25-1 Kitaotsuka 2-chom, Toshima-ku Tokyo 04, JP)
Download PDF: