Title:
NOVEL LIPID
Document Type and Number:
WIPO Patent Application WO/2012/108397
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel cationic lipid which forms lipid particles.
Provided are: a compound represented by formula (I); lipid particles which contain the compound; nucleic acid lipid particles which contain the lipid particles; and a pharmaceutical product which contains the nucleic acid lipid particles as an active ingredient.
Inventors:
KOIZUMI MAKOTO
NAKADA TAKASHI
NAKAYAMA MAKIKO
ONISHI YOSHIYUKI
SATO MIHO
MORITA KOJI
NIWA TAKAKO
SHIBUYA SATOSHI
TAMURA MASAKAZU
NAKADA TAKASHI
NAKAYAMA MAKIKO
ONISHI YOSHIYUKI
SATO MIHO
MORITA KOJI
NIWA TAKAKO
SHIBUYA SATOSHI
TAMURA MASAKAZU
Application Number:
PCT/JP2012/052661
Publication Date:
August 16, 2012
Filing Date:
February 07, 2012
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
KOIZUMI MAKOTO
NAKADA TAKASHI
NAKAYAMA MAKIKO
ONISHI YOSHIYUKI
SATO MIHO
MORITA KOJI
NIWA TAKAKO
SHIBUYA SATOSHI
TAMURA MASAKAZU
KOIZUMI MAKOTO
NAKADA TAKASHI
NAKAYAMA MAKIKO
ONISHI YOSHIYUKI
SATO MIHO
MORITA KOJI
NIWA TAKAKO
SHIBUYA SATOSHI
TAMURA MASAKAZU
International Classes:
C07C217/28; A61K9/127; A61K31/341; A61K31/397; A61K31/40; A61K31/4025; A61K31/445; A61K31/7088; A61K48/00; A61P35/00; C07C229/12; C07D205/04; C07D207/08; C07D211/42; C07D307/20; C07D405/06; C12N15/09
Domestic Patent References:
| WO2009129387A2 | 2009-10-22 | |||
| WO2011006453A1 | 2011-01-20 | |||
| WO2011136368A1 | 2011-11-03 | |||
| WO2011136369A1 | 2011-11-03 |
Foreign References:
| JP2008501729A | 2008-01-24 |
Other References:
BHATTACHARYA ET AL.: "Cationic Oxyethylene Lipids. Synthesis, Aggregation, and Transfection Properties", BIOCONJUGATE CHEM, vol. 15, no. 3, 2004, pages 508 - 519
BHATTACHARYA ET AL.: "Membrane-Forming Properties of Cationic Lipids Bearing Oxyethylene-Based Linkages", JOURNAL OF PHYSICAL CHEMISTRY B, vol. 107, no. 16, 2003, pages 3719 - 3725
DILEEP ET AL.: "Incorporation of oxyethylene units between hydrocarbon chain and pseudoglyceryl backbone in cationic lipid potentiates gene transfection efficiency in the presence of serum", FEBS LETTERS, vol. 509, no. 2, 2001, pages 327 - 331
BHATTACHARYA ET AL.: "Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone", TETRAHEDRON LETTERS, vol. 40, no. 46, 1999, pages 8167 - 8171
BHATTACHARYA ET AL.: "Membrane-Forming Properties of Cationic Lipids Bearing Oxyethylene-Based Linkages", JOURNAL OF PHYSICAL CHEMISTRY B, vol. 107, no. 16, 2003, pages 3719 - 3725
DILEEP ET AL.: "Incorporation of oxyethylene units between hydrocarbon chain and pseudoglyceryl backbone in cationic lipid potentiates gene transfection efficiency in the presence of serum", FEBS LETTERS, vol. 509, no. 2, 2001, pages 327 - 331
BHATTACHARYA ET AL.: "Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone", TETRAHEDRON LETTERS, vol. 40, no. 46, 1999, pages 8167 - 8171
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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Claims: