Title:
NOVEL LIPOIC ACID HETEROCYCLIC OR BENZENE DERIVATIVES, PREPARATION AND USE THEREOF AS MEDICINES
Document Type and Number:
WIPO Patent Application WO2001068643
Kind Code:
A3
Abstract:
The invention concerns novel heterocyclic or benzene derivatives comprising a lateral chain derived from lipoic acid, having an activity inhibiting NO-synthase enzymes producing NO nitrogen monoxide and/or are agents enabling regeneration of antioxidants or entities trapping reactive oxygen species (ROS) and intervening more generally in the redox status of thiol groups. The invention also concerns methods for preparing them, pharmaceutical compositions containing them and their therapeutic use, particularly their use as NO-synthase inhibitors and/or as agents involved more generally in the redox status of thiol groups.
Inventors:
HARNETT JEREMIAH (FR)
AUGUET MICHEL (FR)
AUGUET MICHEL (FR)
Application Number:
PCT/FR2001/000764
Publication Date:
June 06, 2002
Filing Date:
March 15, 2001
Export Citation:
Assignee:
SOD CONSEILS RECH APPLIC (FR)
HARNETT JEREMIAH (FR)
AUGUET MICHEL (FR)
HARNETT JEREMIAH (FR)
AUGUET MICHEL (FR)
International Classes:
A61K31/385; A61K31/4535; A61K31/496; A61P1/08; A61P3/04; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P13/12; A61P15/08; A61P15/10; A61P25/00; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/36; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P37/06; A61P43/00; C07D295/185; C07D333/38; C07D339/04; C07D409/12; C07D409/14; (IPC1-7): C07D409/12; C07D339/04; C07D333/38; A61K31/385; A61P9/00
Domestic Patent References:
| WO2000059899A1 | 2000-10-12 |
Foreign References:
| EP0869126A1 | 1998-10-07 | |||
| FR2761066A1 | 1998-09-25 | |||
| US6030985A | 2000-02-29 | |||
| EP0798292A1 | 1997-10-01 | |||
| FR2801053A1 | 2001-05-18 |
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