Title:
NOVEL LIVER CIRRHOSIS OR LIVER FIBROSIS MARKER
Document Type and Number:
WIPO Patent Application WO/2018/041147
Kind Code:
A1
Abstract:
An application of Golgi protein 73 (GP73) and a substance, used for detecting the concentration of GP73, in preparation of a product for screening or assisting in diagnosing liver cirrhosis-related or liver fibrosis-related diseases, or in preparation of a product for assisting in determining prognosis of a disease. It is proved that GP73 can serve as a novel liver cirrhosis marker. Particularly, GP73 also has diagnostic value on liver cirrhosis caused by non-b hepatitis virus infection, while has no diagnostic value on primary liver cancer.
Inventors:
LU FENGMIN (CN)
YAO MINGJIE (CN)
ZHAO JINGMIN (CN)
YAO MINGJIE (CN)
ZHAO JINGMIN (CN)
Application Number:
PCT/CN2017/099714
Publication Date:
March 08, 2018
Filing Date:
August 30, 2017
Export Citation:
Assignee:
LU FENGMIN (CN)
YAO MINGJIE (CN)
ZHAO JINGMIN (CN)
YAO MINGJIE (CN)
ZHAO JINGMIN (CN)
International Classes:
G01N33/68
Domestic Patent References:
| WO2005026687A2 | 2005-03-24 |
Foreign References:
| CN105189549A | 2015-12-23 | |||
| CN106405104A | 2017-02-15 | |||
| CN101328214A | 2008-12-24 | |||
| CN101735319A | 2010-06-16 | |||
| CN103604918A | 2014-02-26 | |||
| US20140134606A1 | 2014-05-15 |
Other References:
LU , FENGMIN: "Serological diagnosis of hepatocellular carcinoma: challenges and opportunities", JOURNAL OF CLINICAL HEPATOLOGY, vol. 33, no. 7, 31 July 2017 (2017-07-31), pages 1262 - 1265, XP009513598, ISSN: 1001-5256, DOI: 10.3969/j.issn.1001-5256.2017.07.011
QIAO, Y. ET AL.: "Serum gp73 is also a biomarker for diagnosing cirrhosis in population with chronic HBV infection", CLINICAL BIOCHEMISTRY, vol. 47, 25 August 2014 (2014-08-25), pages 216 - 222, XP029091575, DOI: doi:10.1016/j.clinbiochem.2014.08.010
TAN, QIWEN ET AL.: "Value of Golgi protein 73(GP73) for diagnosis and grading of liver cirrhosis", JOURNAL OF DIAGNOSTICS CONCEPTS & PRACTICE, vol. 12, no. 5, 31 December 2013 (2013-12-31), pages 516 - 521, XP009513624, ISSN: 1671-2870
See also references of EP 3508856A4
QIAO, Y. ET AL.: "Serum gp73 is also a biomarker for diagnosing cirrhosis in population with chronic HBV infection", CLINICAL BIOCHEMISTRY, vol. 47, 25 August 2014 (2014-08-25), pages 216 - 222, XP029091575, DOI: doi:10.1016/j.clinbiochem.2014.08.010
TAN, QIWEN ET AL.: "Value of Golgi protein 73(GP73) for diagnosis and grading of liver cirrhosis", JOURNAL OF DIAGNOSTICS CONCEPTS & PRACTICE, vol. 12, no. 5, 31 December 2013 (2013-12-31), pages 516 - 521, XP009513624, ISSN: 1671-2870
See also references of EP 3508856A4
Attorney, Agent or Firm:
F&S INTELLECTUAL PROPERTY LTD. (CN)
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