Title:
NOVEL LOBARIC ACID DERIVATIVE HAVING PTP-1B INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/034173
Kind Code:
A1
Abstract:
The present invention relates to a novel derivative of lobaric acid, a preparation method therefor and a use thereof, and relates to: a novel lobaric acid derivative which has excellent PTP-1B inhibitory activity that is far higher than that of conventional lobaric acid derivatives and which can be orally administered, and thus is very effective in the prevention or treatment of diabetes or obesity through oral administration; a preparation method therefor; and a use thereof.
Inventors:
YIM JOUNG HAN (KR)
KIM IL CHAN (KR)
HAN SE JONG (KR)
KIM TAI KYOUNG (KR)
JO DONG GYU (KR)
OH HYUN CHEOL (KR)
PARK HA JU (KR)
MIN SEUL KI (KR)
KIM SUNG JIN (KR)
KANG PIL SUNG (KR)
KIM MIN JU (KR)
KIM JUNG EUN (KR)
KIM KYUNG HEE (KR)
HONG JU MI (KR)
KIM IL CHAN (KR)
HAN SE JONG (KR)
KIM TAI KYOUNG (KR)
JO DONG GYU (KR)
OH HYUN CHEOL (KR)
PARK HA JU (KR)
MIN SEUL KI (KR)
KIM SUNG JIN (KR)
KANG PIL SUNG (KR)
KIM MIN JU (KR)
KIM JUNG EUN (KR)
KIM KYUNG HEE (KR)
HONG JU MI (KR)
Application Number:
PCT/KR2020/095109
Publication Date:
February 25, 2021
Filing Date:
August 14, 2020
Export Citation:
Assignee:
SNBIOSCIENCE INC (KR)
International Classes:
C07C235/84; A61K31/195; A61K45/06; A61P3/10; C07C231/10; C07D321/10
Foreign References:
| KR101485162B1 | 2015-01-26 | |||
| US20040214870A1 | 2004-10-28 | |||
| KR20100021489A | 2010-02-24 | |||
| JP4419571B2 | 2010-02-24 |
Other References:
CARPENTIER CLAUDIA, XAVIER BARBEAU, JABRANE AZELMAT, KATY VAILLANCOURT, DANIEL GRENIER, PATRICK LAGÜE, NORMAND VOYER: "Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, vol. 26, pages 5845 - 5851, XP055782224
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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