Title:
NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES
Document Type and Number:
WIPO Patent Application WO1999051565
Kind Code:
A9
Abstract:
Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na<+> channel to modulate the biological processes/functions thereof.
Inventors:
AXT SABINE M (US)
CHURCH TIMOTHY J (US)
HRUZEWICZ WITOLD (US)
JACOBSEN JOHN R (US)
JENKINS THOMAS E (US)
JI YU-HUA (US)
JUDICE KEVIN J (US)
CHURCH TIMOTHY J (US)
HRUZEWICZ WITOLD (US)
JACOBSEN JOHN R (US)
JENKINS THOMAS E (US)
JI YU-HUA (US)
JUDICE KEVIN J (US)
Application Number:
PCT/US1999/007263
Publication Date:
December 02, 1999
Filing Date:
April 02, 1999
Export Citation:
Assignee:
ADVANCED MEDICINE INC (US)
AXT SABINE M (US)
CHURCH TIMOTHY J (US)
HRUZEWICZ WITOLD (US)
JACOBSEN JOHN R (US)
JENKINS THOMAS E (US)
JI YU HUA (US)
JUDICE KEVIN J (US)
AXT SABINE M (US)
CHURCH TIMOTHY J (US)
HRUZEWICZ WITOLD (US)
JACOBSEN JOHN R (US)
JENKINS THOMAS E (US)
JI YU HUA (US)
JUDICE KEVIN J (US)
International Classes:
A61K31/16; A61K31/33; A61K31/395; A61K31/445; A61P23/02; C07D241/12; A61P25/04; C07C233/04; C07C237/04; C07C237/34; C07D211/60; C07D211/62; C07D255/02; C07D273/00; C07D273/08; (IPC1-7): C07C233/04; C07D273/08; A61K31/16; A61K31/33; A61K31/445
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