NOVEL MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER OR AUTOIMMUNE DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT

Title:

NOVEL MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER OR AUTOIMMUNE DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2023/022430

Kind Code:

A1

Abstract:

The present invention relates to a novel macrocyclic compound, a preparation method therefor, and a pharmaceutical composition for preventing or treating cancer or autoimmune diseases, containing same as an active ingredient. A compound represented by chemical formula 1 disclosed in the present specification exhibits excellent cytotoxicity against cancer cells while exhibiting excellent inhibitory activity against glutaminase, and thus is expected to be useful for cancer or autoimmune diseases.

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Inventors:

LEE KWANGHO (KR)
DUGGIRALA KRISHNA BABU (KR)
LEE YUJIN (KR)
CHOI GILDON (KR)
CHAE CHONG HAK (KR)
JUNG MYOUNG EUN (KR)
CHO BYOUNG CHUL (KR)
YUN MI RAN (KR)

Application Number:

PCT/KR2022/011939

Publication Date:

February 23, 2023

Filing Date:

August 10, 2022

Export Citation:

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Assignee:

KOREA RES INST CHEMICAL TECH (KR)
UNIV YONSEI IACF (KR)

International Classes:

C07D487/18; A23L33/10; A61K31/504; A61P35/00; A61P37/00

Domestic Patent References:

WO2013078123A1

2013-05-30

Foreign References:

CN111440199A	2020-07-24
US20150065486A1	2015-03-05
KR20150091389A	2015-08-10

Other References:

XU XI, WANG JUBO, WANG MIN, YUAN XINYU, LI LEI, ZHANG CHAO, HUANG HUIDAN, JING TIAN, WANG CHENCHEN, TONG CHAO, ZHOU LIWEN, MENG YI: "Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, no. 8, 22 April 2021 (2021-04-22), US , pages 4588 - 4611, XP093036248, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c02044

Attorney, Agent or Firm:

LEE, Won Hee (KR)

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