Title:
NOVEL MACROCYCLIC OPIOID PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2022/150167
Kind Code:
A3
Abstract:
The disclosure relates to macrocyclic peptides and pharmaceutical compositions thereof. The disclosure further relates to pharmaceutical compositions for modulating opioid receptor activity. The macrocyclic tetrapeptides provided herein are useful in treating diseases or disorders relating to the activity of one or more opioid receptors, such as neurological disorders.
Inventors:
ALDRICH JANE (US)
MCLAUGHLIN JAY (US)
YAKOVLEV DMITRY (US)
MCLAUGHLIN JAY (US)
YAKOVLEV DMITRY (US)
Application Number:
PCT/US2021/063892
Publication Date:
September 29, 2022
Filing Date:
December 16, 2021
Export Citation:
Assignee:
UNIV FLORIDA (US)
International Classes:
A61K38/07; A61K38/12; A61P25/30
Domestic Patent References:
| WO2019204488A1 | 2019-10-24 | |||
| WO2019183556A1 | 2019-09-26 | |||
| WO2001007042A1 | 2001-02-01 |
Other References:
DOLLE, RE ET AL.: "Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 13, 1 July 2009 (2009-07-01), pages 3647 - 3649, XP026155127, DOI: 10.1016/j.bmcl.2009.04.105
Attorney, Agent or Firm:
HSI, Jeffrey, D. et al. (US)
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