Title:
NOVEL MACROLIDE-BASED COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MALARIA AND CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/080072
Kind Code:
A3
Abstract:
The present invention relates to a novel macrolide-based compound, a method for producing the same, and a pharmaceutical composition, which is for preventing or treating malaria and contains the novel macrolide-based compound as an active ingredient. The macrolide-based compound represented by chemical formula 1 according to the present invention effectively exhibits an antiprotozoal activity against Plasmodium sp. protozoan, and thus can be usefully used to prevent or treat malaria.
Inventors:
AHN JONG SEOG (KR)
JANG JAE-HYUK (KR)
KO SUNG-KYUN (KR)
RYOO IN JA (KR)
SON SANG KEUN (KR)
KIM BO YEON (KR)
SOUNG NAK KYUN (KR)
LEE KYUNG HO (KR)
HONG YOUNG-SOO (KR)
JANG JAE-HYUK (KR)
KO SUNG-KYUN (KR)
RYOO IN JA (KR)
SON SANG KEUN (KR)
KIM BO YEON (KR)
SOUNG NAK KYUN (KR)
LEE KYUNG HO (KR)
HONG YOUNG-SOO (KR)
Application Number:
PCT/KR2017/011396
Publication Date:
August 09, 2018
Filing Date:
October 16, 2017
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C07H17/08; A61K31/70; C12N1/20
Domestic Patent References:
| WO2007023370A1 | 2007-03-01 | |||
| WO2016033023A2 | 2016-03-03 | |||
| WO2000026224A2 | 2000-05-11 |
Other References:
KIM, G. S.: "P29 A Novel Glycosylated Macrolide from a Rare Actinomycete, Catenulispora sp. 13F217", NATURAL PRODUCT DISCOVERY & DEVELOPMENT IN THE POST GENOMIC ERA, 11 January 2015 (2015-01-11), XP055537508
WILLIAMS, P. G.: "Arenicolides A-C, 26-Membered Ring Macrolides from the Marine Actinomycete Salinispora arenicola", J. ORG. CHEM., vol. 72, no. 14, 6 July 2007 (2007-07-06), pages 5025 - 5034, XP055537512
GOODMAN, C. D.: "Chemobiosynthesis of New Antimalarial Macrolides", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 57, no. 2, February 2013 (2013-02-01), pages 907 - 913, XP055537515
OTOGURO, K.: "In vitro and in vivo antimalarial activities of a non- glycosidic 18-membered macrolide antibiotic, borrelidin, against drug- resistant strains of Plasmodia", THE JOURNAL OF ANTIBIOTICS, vol. 56, no. 8, August 2003 (2003-08-01), pages 727 - 729, XP055537516
WILLIAMS, P. G.: "Arenicolides A-C, 26-Membered Ring Macrolides from the Marine Actinomycete Salinispora arenicola", J. ORG. CHEM., vol. 72, no. 14, 6 July 2007 (2007-07-06), pages 5025 - 5034, XP055537512
GOODMAN, C. D.: "Chemobiosynthesis of New Antimalarial Macrolides", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 57, no. 2, February 2013 (2013-02-01), pages 907 - 913, XP055537515
OTOGURO, K.: "In vitro and in vivo antimalarial activities of a non- glycosidic 18-membered macrolide antibiotic, borrelidin, against drug- resistant strains of Plasmodia", THE JOURNAL OF ANTIBIOTICS, vol. 56, no. 8, August 2003 (2003-08-01), pages 727 - 729, XP055537516
Attorney, Agent or Firm:
AHN, So Young (KR)
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