Title:
NOVEL MEMBRANE-SECRETED PROTEIN
Document Type and Number:
WIPO Patent Application WO/1998/043998
Kind Code:
A1
Abstract:
Three genes encoding membrane-secreted proteins have been successfully isolated from osteoblast-like cell lines by using a method for specifically cloning membrane-secreted proteins. As the result of subsequent analysis on one of these genes, it has been found out that the protein encoded by this gene is a novel receptor protein which has an extracellular region alone, binds to cell membranes via a GPI anchor and carries therein a cysteine-rich repetitive region conserved in the TNF receptor super family. It has been also found out that when this protein is largely expressed in an osteoblast-like cell line, the proliferation of the cells are suppressed, the cells are morphologically changed, and the alkaline phosphatase activity which is one of the indications of the differentiation of osteoblasts is elevated.
Inventors:
KIMURA NAOKI (JP)
TOYOSHIMA TOMOKO (JP)
TOYOSHIMA TOMOKO (JP)
Application Number:
PCT/JP1998/001511
Publication Date:
October 08, 1998
Filing Date:
April 01, 1998
Export Citation:
Assignee:
CHUGAI RES INST MOLECULAR MED (JP)
KIMURA NAOKI (JP)
TOYOSHIMA TOMOKO (JP)
KIMURA NAOKI (JP)
TOYOSHIMA TOMOKO (JP)
International Classes:
C07K14/705; C12N15/12; C12P21/04; G01F11/18; G01F11/40; (IPC1-7): C07K14/51; C12N15/12; C12N5/10; C07K16/18
Foreign References:
| JPH07118296A | 1995-05-09 | |||
| JPH0931098A | 1997-02-04 | |||
| JPH08510446A | 1996-11-05 | |||
| JPH09501305A | 1997-02-10 |
Other References:
See also references of EP 0976764A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, JP)
Download PDF:
Previous Patent: NOVEL ANTI-HIV COMPLEXES AND MEDICINAL COMPOSITIONS
Next Patent: SINGLE-CHAIN DOUBLE-ALPHA PEPTIDE
Next Patent: SINGLE-CHAIN DOUBLE-ALPHA PEPTIDE