Title:
NOVEL METHOD FOR ANALYZING DATA COLLECTED BY MICROARRAY EXPERIMENT AND THE LIKE
Document Type and Number:
WIPO Patent Application WO/2005/034003
Kind Code:
A1
Abstract:
A method for analyzing data comprising the steps of (1) determining a threshold on the basis of a data value such that the remainder of the subtraction of the background strength from the measured signal strength is negative and determining the range in which the quantitativeness of the logarithmic ratio between the signal value in a comparative experiment and that of the object experiment is assured by the threshold, (2) dividing the average strength into sections, calculating the average of the logarithmic ratios between the above-mentioned signal values in the sections, and correcting the deviation of when the logarithmic ratio is plotted with respect to the average strength, and (3) determining whether or not there is any correlation between the expression profiles of flanking genes determined by a microarray experiment or the like and predicting the transcription unit on a microorganism genome with high accuracy.
Inventors:
IKEMURA TOSHIMICHI (JP)
KANAYA SHIGEHIKO (JP)
WADA KEN-NOSUKE (JP)
MASUDA YASUSHI (JP)
NISHI TATSUYA (JP)
OGASAWARA NAOTAKE (JP)
KOBAYASHI KAZUO (JP)
KANAYA SHIGEHIKO (JP)
WADA KEN-NOSUKE (JP)
MASUDA YASUSHI (JP)
NISHI TATSUYA (JP)
OGASAWARA NAOTAKE (JP)
KOBAYASHI KAZUO (JP)
Application Number:
PCT/JP2003/015637
Publication Date:
April 14, 2005
Filing Date:
December 05, 2003
Export Citation:
Assignee:
JAPAN PRESIDENT NAT INST GENETICS (JP)
IKEMURA TOSHIMICHI (JP)
KANAYA SHIGEHIKO (JP)
WADA KEN-NOSUKE (JP)
MASUDA YASUSHI (JP)
NISHI TATSUYA (JP)
OGASAWARA NAOTAKE (JP)
KOBAYASHI KAZUO (JP)
IKEMURA TOSHIMICHI (JP)
KANAYA SHIGEHIKO (JP)
WADA KEN-NOSUKE (JP)
MASUDA YASUSHI (JP)
NISHI TATSUYA (JP)
OGASAWARA NAOTAKE (JP)
KOBAYASHI KAZUO (JP)
International Classes:
G01N33/53; G16B25/30; C12N15/09; C12Q1/68; G01N33/48; G01N33/566; G01N37/00; G06F17/18; G06N3/12; G16B40/10; (IPC1-7): G06F19/00; G06F17/18; G01N33/48
Foreign References:
| JP2003256407A | 2003-09-12 | |||
| JP2002512367A | 2002-04-23 | |||
| JP2002533701A | 2002-10-08 |
Other References:
SHIMIZU H. ET AL.: "Operon prediction by DNa microarray (an approach with a Bayesian hierarchical model)", TECHNICAL REPORT OF IEICE, vol. 103, no. 150, 26 February 2003 (2003-02-26), pages 23 - 28, XP002977894
SABATTI C. ET AL.: "Co-expression pattern from DNA microarray experiments as a tool for operon prediction", NUCLEIC ACIDS RESEARCH, vol. 30, no. 13, 2002, pages 2886 - 2893, XP002977895
SABATTI C. ET AL.: "Co-expression pattern from DNA microarray experiments as a tool for operon prediction", NUCLEIC ACIDS RESEARCH, vol. 30, no. 13, 2002, pages 2886 - 2893, XP002977895
Attorney, Agent or Firm:
Tsuburaya, Toru (Osaka Ekimae Dai-3 Bldg. 1-3, Umeda 1-chome, Kita-k, Osaka-shi Osaka, JP)
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