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Title:
NOVEL METHOD FOR PRODUCING ANTIBODY-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2019/044946
Kind Code:
A1
Abstract:
A method for producing a compound represented by formula (C), the method comprising a step for converting a compound represented by formula (B) (wherein R1 represents an amino group protected by a protecting group) by intramolecular cyclization into a compound represented by formula (C) (wherein R1 is defined as above).

Inventors:
NISHI Yoshio (LIMITED 3-5-1, Nihonbashi Honcho, Chuo-k, Tokyo 26, 〒1038426, JP)
SAKANISHI Kohei (LIMITED 3-5-1, Nihonbashi Honcho, Chuo-k, Tokyo 26, 〒1038426, JP)
NOGUCHI Shigeru (LIMITED 3-5-1, Nihonbashi Honcho, Chuo-k, Tokyo 26, 〒1038426, JP)
TAKEDA Tadahiro (LIMITED 3-5-1, Nihonbashi Honcho, Chuo-k, Tokyo 26, 〒1038426, JP)
Application Number:
JP2018/032055
Publication Date:
March 07, 2019
Filing Date:
August 30, 2018
Export Citation:
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Assignee:
DAIICHI SANKYO COMPANY, LIMITED (3-5-1, Nihonbashi Honcho Chuo-k, Tokyo 26, 〒1038426, JP)
International Classes:
C07C231/12; A61K31/4745; A61K39/395; A61K47/68; A61P35/00; C07C233/15; C07C233/33; C07C233/54; C07D491/22; C07K7/06; C07K16/00; C07K16/28; C07B61/00
Domestic Patent References:
WO2015146132A12015-10-01
WO2018135501A12018-07-26
Foreign References:
JP2002527420A2002-08-27
JP2009155273A2009-07-16
JPH03279343A1991-12-10
JP2004189620A2004-07-08
US6156761A2000-12-05
US5637770A1997-06-10
US20010034446A12001-10-25
US5849945A1998-12-15
JPH0687746A1994-03-29
US20160333112A12016-11-17
US20150297748A12015-10-22
US20150352224A12015-12-10
US20160297890A12016-10-13
US20170035906A12017-02-09
US20170021031A12017-01-26
Other References:
DATABASE CAS 21 June 2016 (2016-06-21), retrieved from stn Database accession no. 1936451-40-9
GREENE, T. W. ET AL: "PROTECTIVE GROUP IN ORGANIC SYNTHESIS THIRD EDITION", 1999, pages: 552 - 555
BIGGS, D. F. ET AL.: "Monoquaternary neuromuscular blocking agents based on 1-tetralone and 1-indanone", JOURNAL OF MEDICINAL CHEMISTRY, vol. 19, no. 4, April 1976 (1976-04-01), pages 472 - 475, XP055581132
SUGIMORI, M. ET AL.: "Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues", J. MED. CHEM., vol. 41, no. 13, 1998, pages 2308 - 2318, XP002239569
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (LIMITED 1-2-58, Hiromachi, Shinagawa-k, Tokyo 05, 〒1400005, JP)
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