Title:
NOVEL METHOD FOR PRODUCING BENZYLIDENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2004/089921
Kind Code:
A1
Abstract:
A method for producing a compound represented by the formula (I): (wherein R1, R2 and R3 independently represent a lower alkyl) is characterized by conducting a dehydration reaction of a compound represented by the formula (II): (wherein R1, R2 and R3 are as defined above) in the presence of H2O under a basic condition.
Inventors:
ODA KATSUO (JP)
Application Number:
PCT/JP2004/005024
Publication Date:
October 21, 2004
Filing Date:
April 07, 2004
Export Citation:
Assignee:
SHIONOGI & CO (JP)
ODA KATSUO (JP)
ODA KATSUO (JP)
International Classes:
C07D275/02; (IPC1-7): C07D275/02
Other References:
MASANAO INAGAKI ET AL: "Short Synthesis of tert-Butyl-Hydroxlated 3,5-Di-tert-butyl-4-hydroxybenzaldehyde: Synthesis of tert-Butyl-Hydroxylated S2474", J. ORG. CHEM., vol. 68, no. 3, 7 February 2003 (2003-02-07), pages 1128 - 1131, XP001143725
MASANAO INAGAKI ET AL: "Highly E-Selective and Effective Synthesis of Antiarthritic Drug Candidate S-2474 Using Quinone Methide Derivatives", J. ORG. CHEM., vol. 67, no. 1, 2002, pages 125 - 128, XP002979906
NGUYEN-HAI NAM ET AL: "Synthesis and Cytotoxicity of some Rigid Derivatives of Methyl 2,5-Dihydroxycinnamate", ARCHIVES OF PHARMACAL RESEARCH, vol. 25, no. 5, 2002, pages 590 - 599, XP002979907
MASANAO INAGAKI ET AL: "Highly E-Selective and Effective Synthesis of Antiarthritic Drug Candidate S-2474 Using Quinone Methide Derivatives", J. ORG. CHEM., vol. 67, no. 1, 2002, pages 125 - 128, XP002979906
NGUYEN-HAI NAM ET AL: "Synthesis and Cytotoxicity of some Rigid Derivatives of Methyl 2,5-Dihydroxycinnamate", ARCHIVES OF PHARMACAL RESEARCH, vol. 25, no. 5, 2002, pages 590 - 599, XP002979907
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Intellectual Property Depertment 12-4
Sagisu 5-chome, Fukushima-ku, Osaka-sh, Osaka 02, JP)
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