Title:
NOVEL METHOD FOR TREATING CARDIAC INFARCTION USING HMGB1 FRAGMENT
Document Type and Number:
WIPO Patent Application WO/2014/065347
Kind Code:
A1
Abstract:
A fragment peptide that is composed of a part of HMGB1 protein and has a proper length is synthesized, and it is confirmed that the peptide has a therapeutic effect on cardiac infarction.
Inventors:
TAMAI KATSUTO (JP)
KAMATA SOKICHI (JP)
KANEDA YASUFUMI (JP)
MIYAGAWA SHIGERU (JP)
SAWA YOSHIKI (JP)
YAMAZAKI TAKEHIKO (JP)
KAMATA SOKICHI (JP)
KANEDA YASUFUMI (JP)
MIYAGAWA SHIGERU (JP)
SAWA YOSHIKI (JP)
YAMAZAKI TAKEHIKO (JP)
Application Number:
PCT/JP2013/078758
Publication Date:
May 01, 2014
Filing Date:
October 24, 2013
Export Citation:
Assignee:
GENOMIX CO LTD (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
A61K38/16; A61P9/10; C07K14/52
Domestic Patent References:
| WO2012147470A1 | 2012-11-01 | |||
| WO2008053892A1 | 2008-05-08 | |||
| WO2008053892A1 | 2008-05-08 | |||
| WO2007015546A1 | 2007-02-08 | |||
| WO2009133939A1 | 2009-11-05 | |||
| WO2009133940A1 | 2009-11-05 | |||
| WO2004004763A2 | 2004-01-15 | |||
| WO2002074337A1 | 2002-09-26 |
Foreign References:
| JP2005537253A | 2005-12-08 | |||
| JP2005512507A | 2005-05-12 | |||
| JPH09227403A | 1997-09-02 |
Other References:
KITAHARA T. ET AL.: "High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice.", CARDIOVASC. RES., vol. 80, no. 1, 2008, pages 40 - 46, XP055250149
LIMANA F. ET AL.: "Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac c-Kit+ cell proliferation and differentiation.", CIRC. RES., vol. 97, 2005, pages E73 - E83, XP055250136
KUNIHIKO TAKAHASHI ET AL.: "HMGB1 no Kosokugo no Mansei Shinfuzen ni Taisuru Koka -Saibo Chiryo no Chiryo Koka ni Kansuru Aratana Mechanism", ACTA CARDIOLOGICA PAEDIATRICA JAPONICA, vol. 27, 2011, pages S189, XP008179209
KOHNO T. ET AL.: "High mobility group box 1 protein is associated with post-infarction healing process and left ventricular remodeling.", CIRC. J., vol. 72, no. 1, 2008, pages 510 - 511, XP055250672
YASUCHIKA TAKEISHI ET AL.: "Shinfuzen no Byotai Seiri [Bunshi - System kara Kangaeru Bunshi Kijo] Importance of inflammation and immune response in heart failure: toll-like receptor- mediated signaling pathway and ventricular remodeling after myocardial infarction", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 232, no. 5, 2010, pages 378 - 385, XP008179220
KATSUTO TAMAI ET AL.: "Kakushu Byotai Model to Soyaku Kenkyu 7.Hifu . Enshosei Shikkan 2) Seitainai Kotsuzui Kan'yokei Kan/Zenku Saibo Doin Inshi o Riyo shita Tainai Saisei Yudo Iyaku Kaihatsu no Tenbo", GENE & MEDICINE MOOK, 22 July 2012 (2012-07-22), pages 207 - 212, XP008179446
BUSTIN ET AL., MOL CELL BIOL, vol. 19, 1999, pages 5237 - 5246
HORI ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 25752 - 25761
WANG ET AL., SCIENCE, vol. 285, 1999, pages 248 - 251
MULLER ET AL., EMBO J, vol. 20, 2001, pages 4337 - 4340
GERMANI ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 41 - 5
PALUMBO ET AL., J. CELL BIOL., vol. 164, 2004, pages 441 - 449
MERENMIES ET AL., J. BIOL. CHEM., vol. 266, 1991, pages 16722 - 16729
WU Y ET AL., STEM CELLS, vol. 25, 2007, pages 2648 - 2659
TAMAI ET AL., PROC NATL ACAD SCI U S A., vol. 108, no. 16, 2011, pages 6609 - 6614
YANG ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 59 - 66
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
LIMANA F. ET AL.: "Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac c-Kit+ cell proliferation and differentiation.", CIRC. RES., vol. 97, 2005, pages E73 - E83, XP055250136
KUNIHIKO TAKAHASHI ET AL.: "HMGB1 no Kosokugo no Mansei Shinfuzen ni Taisuru Koka -Saibo Chiryo no Chiryo Koka ni Kansuru Aratana Mechanism", ACTA CARDIOLOGICA PAEDIATRICA JAPONICA, vol. 27, 2011, pages S189, XP008179209
KOHNO T. ET AL.: "High mobility group box 1 protein is associated with post-infarction healing process and left ventricular remodeling.", CIRC. J., vol. 72, no. 1, 2008, pages 510 - 511, XP055250672
YASUCHIKA TAKEISHI ET AL.: "Shinfuzen no Byotai Seiri [Bunshi - System kara Kangaeru Bunshi Kijo] Importance of inflammation and immune response in heart failure: toll-like receptor- mediated signaling pathway and ventricular remodeling after myocardial infarction", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 232, no. 5, 2010, pages 378 - 385, XP008179220
KATSUTO TAMAI ET AL.: "Kakushu Byotai Model to Soyaku Kenkyu 7.Hifu . Enshosei Shikkan 2) Seitainai Kotsuzui Kan'yokei Kan/Zenku Saibo Doin Inshi o Riyo shita Tainai Saisei Yudo Iyaku Kaihatsu no Tenbo", GENE & MEDICINE MOOK, 22 July 2012 (2012-07-22), pages 207 - 212, XP008179446
BUSTIN ET AL., MOL CELL BIOL, vol. 19, 1999, pages 5237 - 5246
HORI ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 25752 - 25761
WANG ET AL., SCIENCE, vol. 285, 1999, pages 248 - 251
MULLER ET AL., EMBO J, vol. 20, 2001, pages 4337 - 4340
GERMANI ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 41 - 5
PALUMBO ET AL., J. CELL BIOL., vol. 164, 2004, pages 441 - 449
MERENMIES ET AL., J. BIOL. CHEM., vol. 266, 1991, pages 16722 - 16729
WU Y ET AL., STEM CELLS, vol. 25, 2007, pages 2648 - 2659
TAMAI ET AL., PROC NATL ACAD SCI U S A., vol. 108, no. 16, 2011, pages 6609 - 6614
YANG ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 59 - 66
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
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