Title:
NOVEL METHOD FOR TREATING SPINAL CORD INJURY USING HMGB1 FRAGMENT
Document Type and Number:
WIPO Patent Application WO/2014/065348
Kind Code:
A1
Abstract:
A fragment peptide that is composed of a part of HMGB1 protein and has a proper length is synthesized, and it is confirmed that the peptide has a therapeutic effect on spinal cord injury.
Inventors:
TAMAI KATSUTO (JP)
YAMAZAKI TAKEHIKO (JP)
CUI WENHAO (JP)
YAMAZAKI TAKEHIKO (JP)
CUI WENHAO (JP)
Application Number:
PCT/JP2013/078759
Publication Date:
May 01, 2014
Filing Date:
October 24, 2013
Export Citation:
Assignee:
GENOMIX CO LTD (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
A61K38/16; A61P25/00; C07K14/52
Domestic Patent References:
| WO2011046570A1 | 2011-04-21 | |||
| WO2009133939A1 | 2009-11-05 | |||
| WO2008053892A1 | 2008-05-08 | |||
| WO2008053892A1 | 2008-05-08 | |||
| WO2007015546A1 | 2007-02-08 | |||
| WO2009133939A1 | 2009-11-05 | |||
| WO2009133943A1 | 2009-11-05 | |||
| WO2009133940A1 | 2009-11-05 | |||
| WO2004004763A2 | 2004-01-15 |
Foreign References:
| JP2005512507A | 2005-05-12 | |||
| JPH09227403A | 1997-09-02 | |||
| JP2007320919A | 2007-12-13 |
Other References:
FANG. P. ET AL.: "HMGB1 contributes to regeneration after spinal cord injury in adult zebrafish.", MOLECULAR NEUROBIOLOGY, vol. 49, no. 1, 31 August 2013 (2013-08-31), pages 472 - 483, XP055250180
HIDEAKI NAKAJIMA ET AL.: "Sonsho Sekizui ni Okeru high mobility group box-l (HMGB-l) no Dotai to Yakuwari", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 84, no. 8, 2010, pages S1050, XP008179099
BUSTIN ET AL., MOL CELL BIOL, vol. 19, 1999, pages 5237 - 5246
HORI ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 25752 - 25761
WANG ET AL., SCIENCE, vol. 285, 1999, pages 248 - 251
MULLER ET AL., EMBO J, vol. 20, 2001, pages 4337 - 4340
GERMANI ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 41 - 5
PALUMBO ET AL., J. CELL BIOL., vol. 164, 2004, pages 441 - 449
MERENMIES ET AL., J. BIOL. CHEM., vol. 266, 1991, pages 16722 - 16729
WU Y ET AL., STEM CELLS, vol. 25, 2007, pages 2648 - 2659
TAMAI ET AL., PROC NATL ACAD SCI U S A., vol. 108, no. 16, 2011, pages 6609 - 6614
YANG ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 59 - 66
BASSO ET AL., J NEUROTRAUMA, vol. 23, no. 5, 2006, pages 635 - 659
RAHIMI-MOVAGHAR ET AL., INT J NEUROSCI., vol. 118, no. 10, 2008, pages 1359 - 1373
QUERTAINMONT R ET AL., PLOS ONE., vol. 7, no. 6, 2012, pages E39500
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
See also references of EP 2913059A4
HIDEAKI NAKAJIMA ET AL.: "Sonsho Sekizui ni Okeru high mobility group box-l (HMGB-l) no Dotai to Yakuwari", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 84, no. 8, 2010, pages S1050, XP008179099
BUSTIN ET AL., MOL CELL BIOL, vol. 19, 1999, pages 5237 - 5246
HORI ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 25752 - 25761
WANG ET AL., SCIENCE, vol. 285, 1999, pages 248 - 251
MULLER ET AL., EMBO J, vol. 20, 2001, pages 4337 - 4340
GERMANI ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 41 - 5
PALUMBO ET AL., J. CELL BIOL., vol. 164, 2004, pages 441 - 449
MERENMIES ET AL., J. BIOL. CHEM., vol. 266, 1991, pages 16722 - 16729
WU Y ET AL., STEM CELLS, vol. 25, 2007, pages 2648 - 2659
TAMAI ET AL., PROC NATL ACAD SCI U S A., vol. 108, no. 16, 2011, pages 6609 - 6614
YANG ET AL., J LEUKOC BIOL., vol. 81, no. 1, 2007, pages 59 - 66
BASSO ET AL., J NEUROTRAUMA, vol. 23, no. 5, 2006, pages 635 - 659
RAHIMI-MOVAGHAR ET AL., INT J NEUROSCI., vol. 118, no. 10, 2008, pages 1359 - 1373
QUERTAINMONT R ET AL., PLOS ONE., vol. 7, no. 6, 2012, pages E39500
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
See also references of EP 2913059A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
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