Title:
NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/030057
Kind Code:
A1
Abstract:
A morpholine derivative represented by general formula [1A] or a salt thereof. In the formula, the ring A represents a ring represented by general formula [I] or the like; * represents a binding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other and independently represent a hydrogen atom or the like; R3, R4 and R5 are the same as or different from one another and independently represent a hydrogen atom, NRaRb or the like; and Ra and Rb independently represent a hydrogen atom, a C1-8 alkyl group which may have a substituent or the like.
Inventors:
KUBO YOHEI (JP)
ANDO MAKOTO (JP)
TANAKA HIDEHIKO (JP)
OSAKA SHUHEI (JP)
MATSUMOTO TAKUYA (JP)
NAKATA HIYOKU (JP)
TERADA DAISUKE (JP)
NITABARU TATSUYA (JP)
ANDO MAKOTO (JP)
TANAKA HIDEHIKO (JP)
OSAKA SHUHEI (JP)
MATSUMOTO TAKUYA (JP)
NAKATA HIYOKU (JP)
TERADA DAISUKE (JP)
NITABARU TATSUYA (JP)
Application Number:
PCT/JP2014/072445
Publication Date:
March 05, 2015
Filing Date:
August 27, 2014
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07D401/14; A61K31/5377; A61K31/5383; A61K31/5386; A61K31/541; A61K31/55; A61K31/553; A61P31/14; A61P35/00; A61P43/00; C07D405/04; C07D405/14; C07D409/04; C07D409/14; C07D411/04; C07D411/14; C07D413/14; C07D417/14; C07D491/048; C07D491/052; C07D491/056; C07D491/107; C07D498/04; C07D498/08
Domestic Patent References:
| WO2005016919A1 | 2005-02-24 |
Foreign References:
| JP2007501836A | 2007-02-01 | |||
| JP2005521689A | 2005-07-21 | |||
| JP2005503414A | 2005-02-03 |
Other References:
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, pages 25571 - 25575
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, 1999, pages 25571 - 25575
NATURE, vol. 421, 2003, pages 499 - 506
EMBO JOURNAL, vol. 19, 2000, pages 463 - 471
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, 1999, pages 31463 - 31467
SCIENCE, vol. 268, 1995, pages 1749 - 1753
SCIENCE, vol. 280, 1998, pages 1089 - 1091
MOLECULAR CELL BIOLOGY, vol. 21, 2001, pages 1164 - 1172
NATURE, vol. 431, 2004, pages 997 - 1002
BLOOD, vol. 5, 2013, pages 180 - 187
CLINICAL CANCER RESEARCH, vol. 15, 2007, pages 4371 - 4377
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC, pages: 696 - 926
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 16 - 299
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 533 - 643
W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 16 - 430
"Experimental Chemistry", vol. 16, MARUZEN PUBLISHING CO., LTD., article "Organic Compound Synthesis IV, carboxylic acid, amino acid, peptide", pages: 258 - 267
RICHARD C. LAROCK ET AL.: "Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC., pages: 823 - 827
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, 1999, pages 25571 - 25575
NATURE, vol. 421, 2003, pages 499 - 506
EMBO JOURNAL, vol. 19, 2000, pages 463 - 471
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, 1999, pages 31463 - 31467
SCIENCE, vol. 268, 1995, pages 1749 - 1753
SCIENCE, vol. 280, 1998, pages 1089 - 1091
MOLECULAR CELL BIOLOGY, vol. 21, 2001, pages 1164 - 1172
NATURE, vol. 431, 2004, pages 997 - 1002
BLOOD, vol. 5, 2013, pages 180 - 187
CLINICAL CANCER RESEARCH, vol. 15, 2007, pages 4371 - 4377
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC, pages: 696 - 926
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 16 - 299
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 533 - 643
W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC., pages: 16 - 430
"Experimental Chemistry", vol. 16, MARUZEN PUBLISHING CO., LTD., article "Organic Compound Synthesis IV, carboxylic acid, amino acid, peptide", pages: 258 - 267
RICHARD C. LAROCK ET AL.: "Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC., pages: 823 - 827
Attorney, Agent or Firm:
NAKAJIMA, Jun et al. (JP)
Nakajima 淳 (JP)
Nakajima 淳 (JP)
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