NOVEL MUTILIN DERIVATIVES

WIPO Patent Application WO/2008/117796

A1

The invention relates to mutilin derivatives represented by the general formula (I) which are useful as antimicrobial agent against multidrug-resistant bacteria; and intermediates for the production of the same. In the general formula (I), R1 is vinyl or the like; P1 is H, an OH-protecting group, or the like; R2 and R3 are each H or the like; G is lower alkylene; A is a single bond or the like; Q1 is a saturated heterocyle; R4 and R5 are each H, lower alkyl, or the like; and W is a group represented by the general formula (W-1), an amino-protecting group, or H; in the general formula (W-1), B is -CO- or the like; X is lower alkylene or the like; Z1 is CH or the like; Z2, Z3 and Z4 are each N or the like; and Y1 and Y2 are each H, amino, a group represented by the general formula (Y-1), or the like; and in the general formula (Y-1), Q2 is a saturated heterocycle; and R7 and R8 are each H, lower alkyl, or the like.

HIROKAWA YOSHIMI (JP)
KATO SHIRO (JP)
KINOSHITA HIRONORI (JP)
TANAKA TOMOYUKI (JP)

PCT/JP2008/055566

October 02, 2008

March 25, 2008

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DAINIPPON SUMITOMO PHARMA CO (JP)
HIROKAWA YOSHIMI (JP)
KATO SHIRO (JP)
KINOSHITA HIRONORI (JP)
TANAKA TOMOYUKI (JP)

C07D241/04; A61K31/395; A61K31/437; A61K31/495; A61K31/519; A61K31/52; A61K31/5377; A61K31/55; A61K31/551; A61P31/04; C07D243/08; C07D245/02; C07D295/20; C07D471/04; C07D473/16; C07D473/18; C07D473/34; C07D487/04

WO2007037518A1	2007-04-05
WO2000037074A1	2000-06-29
WO2002038528A1	2002-05-16
WO2002030929A1	2002-04-18
WO2000007974A1	2000-02-17
WO1999021855A1	1999-05-06

US4278674A

1981-07-14

ISOBE, Yutaka et al. (Dainippon Sumitomo Pharma Co. Ltd.,1-98, Kasugadenaka 3-chome, Konohana-k, Osaka-shi Osaka 22, JP)

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