Title:
NOVEL N-3 IMMUNORESOLVENTS: STRUCTURES AND ACTIONS
Document Type and Number:
WIPO Patent Application WO/2014/193652
Kind Code:
A3
Abstract:
The invention describes novel mono-hydroxy, di-hydroxy and tri-hydroxy docosapentaenoic acid (DPA) analogues, their preparation, isolation, identification, purification and uses thereof. Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidbmics and in vivo systems, endogenous n-3 docosapentaenoic (DP A) acid is converted during inflammation-resolution in mice and by human leukocytes to novel n-3 products congenerous to D-series resolvins (Rv), protectins (PD) and maresins (MaR), termed specialized pro-resolving mediators (SPM). The new n-3 DPA structures include 7,8,17-trihydroxy-9,11,13,15E, 19Zdocosapentaenoic acid (RvD1n_3 DPA), 7, 14-dihydroxy-8, 10, 12, 16Z, 19Z-docosapentaenoic acid (MaR1n_3 DPA) and related bioactive products.
Inventors:
SERHAN CHARLES N (US)
DALLI JESMOND (US)
DALLI JESMOND (US)
Application Number:
PCT/US2014/037969
Publication Date:
February 26, 2015
Filing Date:
May 14, 2014
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
International Classes:
A61K31/202
Domestic Patent References:
| WO2012135032A2 | 2012-10-04 |
Foreign References:
| US20080161274A1 | 2008-07-03 | |||
| US20110178047A1 | 2011-07-21 | |||
| JP2011190184A | 2011-09-29 |
Other References:
DALLI ET AL.: "Novel n-3 Immunoresolvents: Structures and Actions.", SCIENTIFIC REPORTS, vol. 3, no. 1940, 1 June 2013 (2013-06-01), pages 1 - 38, XP055297582, Retrieved from the Internet [retrieved on 20141106]
Attorney, Agent or Firm:
CHRISTENSEN, Douglas J. (33 South Sixth StreetSuite 395, Minneapolis MN, US)
Download PDF:
Previous Patent: VEHICLE-TRANSPORTABLE ICE PLANT
Next Patent: SPRUNG GATE VALVES MOVABLE BY AN ACTUATOR
Next Patent: SPRUNG GATE VALVES MOVABLE BY AN ACTUATOR