Title:
NOVEL N-HETEROCYCLIC BET BROMODOMAIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/116968
Kind Code:
A1
Abstract:
Provided in the present application are a compound of formula (I), a pharmaceutically acceptable salt thereof, a preparation method therefor, and the medical use thereof. The compound can be used as an agent in the treatment of diseases and conditions, and the diseases and conditions include cancer, inflammatory diseases, autoimmune diseases, etc.
Inventors:
ZHU HUI (CN)
ZHANG JIBING (CN)
ZHANG XINLONG (CN)
SHU TIANBO (CN)
ZHANG TAO (CN)
XIANG YAO (CN)
WANG YING (CN)
ZHANG JIBING (CN)
ZHANG XINLONG (CN)
SHU TIANBO (CN)
ZHANG TAO (CN)
XIANG YAO (CN)
WANG YING (CN)
Application Number:
PCT/CN2021/134454
Publication Date:
June 09, 2022
Filing Date:
November 30, 2021
Export Citation:
Assignee:
CHENGDU EASTON BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/407; C07D471/04; A61K31/437; A61P35/00; C07D487/04
Domestic Patent References:
| WO2011054553A1 | 2011-05-12 | |||
| WO2017177955A1 | 2017-10-19 |
Foreign References:
| CN109071534A | 2018-12-21 | |||
| CN106986872A | 2017-07-28 | |||
| CN106414442A | 2017-02-15 | |||
| CN106414442A | 2017-02-15 |
Other References:
CAO, RAN: "Recent Advances of BET Bbromodomain Inhibitors", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 6, 30 June 2020 (2020-06-30), pages 347 - 358, XP055936676
GEORGE S. SHEPPARD, LE WANG, STEVEN D. FIDANZE, LISA A. HASVOLD, DACHUN LIU, JOHN K. PRATT, CHANG H. PARK, KENTON LONGENECKER, WEI: "Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 10, 28 May 2020 (2020-05-28), US , pages 5585 - 5623, XP055716907, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00628
JUNG M ET AL., EPIGENOMICS, vol. 7, no. 3, 2015, pages 487 - 501
NICODEME E ET AL., NATURE, vol. 468, no. 7327, 2010, pages 7327 - 1073
MCLURE KG ET AL., PLOS ONE, vol. 8, no. 12, 2013, pages e83190
BRAND M ET AL., ACS CHEM BIOL, vol. 10, no. 1, 2015, pages 22 - 39
R.C. LUO ET AL.: "Handbook of Pharmaceutical Excipients", 2005, CHEMICAL INDUSTRY PRESS
N. MIYAMAA. SUZUKI, CHEM. REV., vol. 95, 1995, pages 2457 - 2483
J. ORGANOMET. CHEM., vol. 576, 1999, pages 147 - 148
GEORGE S. SHEPPARD, LE WANG, STEVEN D. FIDANZE, LISA A. HASVOLD, DACHUN LIU, JOHN K. PRATT, CHANG H. PARK, KENTON LONGENECKER, WEI: "Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 10, 28 May 2020 (2020-05-28), US , pages 5585 - 5623, XP055716907, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00628
JUNG M ET AL., EPIGENOMICS, vol. 7, no. 3, 2015, pages 487 - 501
NICODEME E ET AL., NATURE, vol. 468, no. 7327, 2010, pages 7327 - 1073
MCLURE KG ET AL., PLOS ONE, vol. 8, no. 12, 2013, pages e83190
BRAND M ET AL., ACS CHEM BIOL, vol. 10, no. 1, 2015, pages 22 - 39
R.C. LUO ET AL.: "Handbook of Pharmaceutical Excipients", 2005, CHEMICAL INDUSTRY PRESS
N. MIYAMAA. SUZUKI, CHEM. REV., vol. 95, 1995, pages 2457 - 2483
J. ORGANOMET. CHEM., vol. 576, 1999, pages 147 - 148
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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