Title:
NOVEL NATURAL PROTEIN AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/006750
Kind Code:
A1
Abstract:
Provided is a secretory protein sDSS1 of a higher primate. The protein can be detected in human blood serum and cerebrospinal fluid. The sDSS1 protein can bind, under non-enzymatic conditions, with an oxidized protein to form a polymer, or bind with an Aβ polypeptide to reduce the formation of an Aβ oligomer. In culture, the sDSS1 protein can shield against cytotoxicity induced by an oxidized protein, Aβ oligomer, amylin oligomer, or glycosylated protein. The sDSS1 protein can significantly extend the survival of a progeria mouse model. The protein can be used to prevent and treat a disease caused by accumulation of an oxidized protein, glycoprotein, Aβ protein, or amylin, or by the generation or accumulation of another pathogenic protein with a similar property.
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Inventors:
ZHANG YINGHAO (CN)
FU JINGPENG (CN)
WAN JIA (CN)
FU JINGPENG (CN)
WAN JIA (CN)
Application Number:
PCT/CN2017/090785
Publication Date:
January 11, 2018
Filing Date:
June 29, 2017
Export Citation:
Assignee:
SHANGHAI QINGLIU BIO-PHARM TECH CO LTD (CN)
International Classes:
C07K14/47; A61K38/17; A61K45/00; A61K48/00; A61P25/28; C07K19/00; C12N5/10; C12N15/12; C12N15/85; C12N15/861; C12N15/867
Other References:
DATABASE GenBank [O] 30 September 2015 (2015-09-30), XP055527813, Database accession no. XP_008960228
DATABASE GenBank [O] 30 September 2015 (2015-09-30), XP055527824, Database accession no. XM_008961980.1
GONG, C.X.: "DSSylation, a Novel Guide for Protein Degradation", PROTEIN CELL, vol. 5, no. 2, 29 January 2014 (2014-01-29), XP035734440
See also references of EP 3444270A4
DATABASE GenBank [O] 30 September 2015 (2015-09-30), XP055527824, Database accession no. XM_008961980.1
GONG, C.X.: "DSSylation, a Novel Guide for Protein Degradation", PROTEIN CELL, vol. 5, no. 2, 29 January 2014 (2014-01-29), XP035734440
See also references of EP 3444270A4
Attorney, Agent or Firm:
BEIJING UTC LIANFENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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