Title:
NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME
Document Type and Number:
WIPO Patent Application WO1999001427
Kind Code:
A3
Abstract:
The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates via the direct reaction of nitric oxide with amidines and enamines, and to a method of converting amines into such compounds.
Inventors:
HRABIE JOSEPH A (US)
KEEFER LARRY K (US)
KEEFER LARRY K (US)
Application Number:
PCT/US1998/013723
Publication Date:
March 25, 1999
Filing Date:
July 01, 1998
Export Citation:
Assignee:
US HEALTH (US)
HRABIE JOSEPH A (US)
KEEFER LARRY K (US)
HRABIE JOSEPH A (US)
KEEFER LARRY K (US)
International Classes:
A61K31/13; A61K31/4164; A61P43/00; C07C251/08; C07D295/06; C07C291/02; C07C291/08; C07D211/72; C07D233/20; C07D233/24; C07D295/023; C07D295/13; C07D405/04; (IPC1-7): C07D291/08; C07D295/12; C07D233/96; A61K31/655
Domestic Patent References:
| WO1996040665A1 | 1996-12-19 | |||
| WO1993013055A1 | 1993-07-08 | |||
| WO1994027957A1 | 1994-12-08 |
Foreign References:
| US5155137A | 1992-10-13 | |||
| US5212204A | 1993-05-18 |
Other References:
CHEMICAL ABSTRACTS, vol. 85, no. 21, 1976, Columbus, Ohio, US; abstract no. 159592w, L.B. VOLODARSKII ET AL: "Preparation and properties of N-nitroso-alpha-hydroxylamino oximes" page 505; XP002087968
J. P. FREEMAN ET AL: "Alkaline decomposition of nitrosohydroxylamine derivatives", JOURNAL OF ORGANIC CHEMISTRY, vol. 35, no. 9, 1970, EASTON US, pages 3107 - 3110, XP002087967
DATABASE WPI Week 8508, Derwent World Patents Index; AN 85-047728, XP002087969, "New N,N'-dihydroxydiazenum propanol derivs. - for prevention and treatment of apple canker"
J. P. FREEMAN ET AL: "Alkaline decomposition of nitrosohydroxylamine derivatives", JOURNAL OF ORGANIC CHEMISTRY, vol. 35, no. 9, 1970, EASTON US, pages 3107 - 3110, XP002087967
DATABASE WPI Week 8508, Derwent World Patents Index; AN 85-047728, XP002087969, "New N,N'-dihydroxydiazenum propanol derivs. - for prevention and treatment of apple canker"
Download PDF: