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Title:
NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/069226
Kind Code:
A1
Abstract:
A compound represented by general formula [I] (in the formula, X represents N or the like, Y represents CH or the like, RA represents an optionally substituted cycloalkyl group or the like, R1 represents an alkyl group or the like, R2 represents an optionally substituted alkyl group or the like, and R3 represents a hydrogen atom or an alkyl group), or a pharmacologically acceptable salt thereof has an inhibitory activity on aldosterone synthase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

Inventors:
SAKAKIBARA, Ryo (3-2-10 Dosho-machi, Chuo-ku, Osaka-sh, Osaka 05, 〒5418505, JP)
USHIROGOCHI, Hideki (3-2-10 Dosho-machi, Chuo-ku, Osaka-sh, Osaka 05, 〒5418505, JP)
SASAKI, Wataru (3-2-10 Dosho-machi, Chuo-ku, Osaka-sh, Osaka 05, 〒5418505, JP)
ONDA, Yuichi (3-2-10 Dosho-machi, Chuo-ku, Osaka-sh, Osaka 05, 〒5418505, JP)
YAMAGUCHI, Minami (3-2-10 Dosho-machi, Chuo-ku, Osaka-sh, Osaka 05, 〒5418505, JP)
AKAHOSHI, Fumihiko (3-2-10 Dosho-machi, Chuo-ku, Osaka-sh, Osaka 05, 〒5418505, JP)
Application Number:
JP2016/081214
Publication Date:
April 27, 2017
Filing Date:
October 21, 2016
Export Citation:
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Assignee:
MITSUBISHI TANABE PHARMA CORPORATION (3-2-10, Dosho-machi Chuo-ku, Osaka-sh, Osaka 05, 〒5418505, JP)
International Classes:
C07D213/74; A61K31/496; A61K31/497; A61K31/501; A61K31/5377; A61K31/5386; A61K31/541; A61P1/16; A61P3/04; A61P3/06; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P25/02; A61P25/04; A61P25/22; A61P25/24; A61P35/00; C07D237/20; C07D241/20; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D405/04; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D451/04; C07D453/02; C07D471/04; C07D498/08
Domestic Patent References:
2014-11-06
2013-06-06
2012-01-26
2010-04-01
2015-10-29
Foreign References:
JP2012526774A2012-11-01
Other References:
HU , Q. ET AL.: "Aldosterone Synthase Inhibitors as Promising Treatments for Mineralocorticoid Dependent Cardiovascular and Renal Diseases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 12, 2014, pages 5011 - 5022, XP055228601, ISSN: 0022-2623
DATABASE REGISTRY [o] 14 May 2010 (2010-05-14), "1-Piperazineacetamide, N,N- dimethyl-4-[6-(1H-1,2,4-triazol-1-yl)-2- pyrazinyl", retrieved from STN Database accession no. 1223591-34-1
DATABASE REGISTRY [o] 3 November 2008 (2008-11-03), "1-Piperazineacetamide, 4- [5-(4-methoxyphenyl)-1,2,4-triazin-3-yl]-N- (1-methylethyl", retrieved from STN Database accession no. 1070398-58-1
DATABASE REGISTRY [o] 2 November 2008 (2008-11-02), "1-Piperazineacetamide, 4- [5-(4-chlorophenyl)-1,2,4-triazin-3-yl]-N,N- dimethyl", retrieved from STN Database accession no. 1069628-74-5
DATABASE REGISTRY [o] 13 October 2008 (2008-10-13), "1-Piperazineacetamide, N,N- dimethyl-4-[5-[4-(trifluoromethyl)phenyl]- 1,2,4-triazin-3-yl", retrieved from STN Database accession no. 1060824-77-2
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower 8-1, Kakuda-cho, Kita-ku, Osaka-sh, Osaka 17, 〒5300017, JP)
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