NOVEL NUCLEIC ACIDS AND PROTEINS WITH GROWTH HORMONE ACTIVITY

WIPO Patent Application WO2000068385

A3

The invention relates to novel growth hormone activity (GHA) proteins and nucleic acids. The invention further relates to the use of the GHA proteins in the treatment of growth hormone related disorders.

FILIKOV ANTON

PCT/US2000/013175

February 15, 2001

May 12, 2000

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XENCOR INC (US)

C12N15/09; A61K38/27; A61P3/04; A61P3/10; A61P5/06; A61P9/00; A61P9/04; A61P13/12; A61P15/00; A61P19/00; A61P21/00; A61P31/18; A61P35/00; A61P43/00; C07K14/61; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/18; C12P21/02; A61K38/00; (IPC1-7): C12N15/18; A61K38/27; C07K14/61; C12N5/10

WO1997011178A1	1997-03-27
WO1998047089A1	1998-10-22

LOWMAN HENRY B ET AL: "Affinity maturation of human growth hormone by monovalent phage display.", JOURNAL OF MOLECULAR BIOLOGY, vol. 234, no. 3, 1993, pages 564 - 578, XP000953072, ISSN: 0022-2836
ULTSCH MARK H ET AL: "The crystal structure of affinity-matured human growth hormone at 2 A resolution.", JOURNAL OF MOLECULAR BIOLOGY, vol. 236, no. 1, 1994, pages 286 - 299, XP000953071, ISSN: 0022-2836
ATWELL SHANE ET AL: "Structural plasticity in a remodeled protein-protein interface.", SCIENCE (WASHINGTON D C), vol. 278, no. 5340, 7 November 1997 (1997-11-07), pages 1125 - 1128, XP002150985, ISSN: 0036-8075
DAHIYAT B I ET AL: "PROTEIN DESIGN AUTOMATION", PROTEIN SCIENCE, vol. 5, no. 5, May 1996 (1996-05-01), pages 895 - 903, XP002073372, ISSN: 0961-8368

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