Title:
NOVEL NUCLEOSIDE ANALOG AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/077800
Kind Code:
A1
Abstract:
Provided is a technique for detecting 8-oxo-dG in DNA with the use of a novel compound represented by formula (I). In formula (I): R1 represents a hydrogen atom, a protecting group for the 3'-hydroxyl group, an oligodeoxynucleotide group 1 (ODN group 1), or -P(OR3)R4 [wherein R3 represents a protecting group for the phosphate group; and R4 represents a dialkylamino group having two C1-6 alkyl groups attached to a nitrogen atom, said C1-6 alkyl groups being the same or different]; and R2 represents a hydrogen atom, a protecting group for the 5'-hydroxyl group, or an oligodeoxynucleotide group 2 (ODN group 2). The compound according to the present invention is useful in detecting oxidative mutation in a nucleic acid.
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Inventors:
SASAKI SHIGEKI (JP)
TANIGUCHI YOSUKE (JP)
KAWAGUCHI RYOTA (JP)
TANIGUCHI YOSUKE (JP)
KAWAGUCHI RYOTA (JP)
Application Number:
PCT/JP2011/078604
Publication Date:
June 14, 2012
Filing Date:
December 09, 2011
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
SASAKI SHIGEKI (JP)
TANIGUCHI YOSUKE (JP)
KAWAGUCHI RYOTA (JP)
SASAKI SHIGEKI (JP)
TANIGUCHI YOSUKE (JP)
KAWAGUCHI RYOTA (JP)
International Classes:
C07H21/04; C07H19/173
Other References:
ZHICHUN LI ET AL.: "Synthesis of new derivatives of 8-oxoG-Clamp for better understanding the recognition mode and improvement of selective affinity", BIOORGANIC & MEDICINAL CHEMISTRY, June 2010 (2010-06-01), pages 3992 - 3998
TAMER NASR ET AL.: "Selective fluorescence quenching of the 8-oxoG- clamp by 8-oxodeoxyguanosine in ODN", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 727 - 730
OSAMU NAKAGAWA ET AL.: "Specific Fluorescent Probe for 8-Oxoguanosine", ANGEW. CHEM. INT. ED., vol. 46, no. 24, 2007, pages 4500 - 4503, XP055133776, DOI: doi:10.1002/anie.200700671
ZHICHUN LI ET AL.: "8-Oxoguanosine Tokuiteki Oto o Shimesu Keiko Probe no Kaihatsu", ABSTRACTS SYMPOSIUM ON PROGRESS IN ORGANIC REACTIONS AND SYNTHESIS, vol. 35, 2009, pages 272 - 273
OSAMU NAKAGAWA ET AL.: "8- Oxoguanosine Keiko Probe no Kaihatsu", ABSTRACTS, SYMPOSIUM ON BIOFUNCTIONAL CHEMISTRY, vol. 22, 2007, pages 88 - 89
ZHICHUN LI ET AL.: "Keiko Probe "8-oxoG -clamp" no 8-Oxoguanosine Ninshiki Mechanism no Kaimei Oyobi Ninshikino no Kojo o Mezashita Shinki Yudotai no Gosei to Hyoka'", BANYU LIFE SCIENCE FOUNDATION INTERNATIONAL, FUKUOKA SYMPOSIUM, vol. 20, May 2010 (2010-05-01), pages 64
TAMER NASR ET AL.: "Selective fluorescence quenching of the 8-oxoG- clamp by 8-oxodeoxyguanosine in ODN", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 727 - 730
OSAMU NAKAGAWA ET AL.: "Specific Fluorescent Probe for 8-Oxoguanosine", ANGEW. CHEM. INT. ED., vol. 46, no. 24, 2007, pages 4500 - 4503, XP055133776, DOI: doi:10.1002/anie.200700671
ZHICHUN LI ET AL.: "8-Oxoguanosine Tokuiteki Oto o Shimesu Keiko Probe no Kaihatsu", ABSTRACTS SYMPOSIUM ON PROGRESS IN ORGANIC REACTIONS AND SYNTHESIS, vol. 35, 2009, pages 272 - 273
OSAMU NAKAGAWA ET AL.: "8- Oxoguanosine Keiko Probe no Kaihatsu", ABSTRACTS, SYMPOSIUM ON BIOFUNCTIONAL CHEMISTRY, vol. 22, 2007, pages 88 - 89
ZHICHUN LI ET AL.: "Keiko Probe "8-oxoG -clamp" no 8-Oxoguanosine Ninshiki Mechanism no Kaimei Oyobi Ninshikino no Kojo o Mezashita Shinki Yudotai no Gosei to Hyoka'", BANYU LIFE SCIENCE FOUNDATION INTERNATIONAL, FUKUOKA SYMPOSIUM, vol. 20, May 2010 (2010-05-01), pages 64
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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