Title:
NOVEL OCTAHYDROPYRIDOQUINAZOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES FOR SAID DERIVATIVE AND COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2014/092006
Kind Code:
A1
Abstract:
[Problem] To provide a novel compound that exhibits an agonistic effect on dopamine D2 receptors. [Solution] A compound that can be represented by general formula (I) (in which R1 represents a C1-6 alkyl or the like; R2 represents hydrogen or the like; R3 and R4 each represent either hydrogen, a C1-6 alkyl, a R10R11N-C1-6 alkyl, an aralkyl, or the like; R5 and R6 each represent hydrogen or the like; and R7 represents hydrogen or the like) or a pharmacologically permitted salt thereof is provided, as are a pharmaceutical composition containing same and uses for said compound/salt and composition. This compound exhibits a superb stimulatory effect on dopamine D2 receptors and thus is useful as a therapeutic or prophylactic agent for Parkinson's disease and the like.
Inventors:
NISHIMURA TOSHIHIRO (JP)
UENO YASUNORI (JP)
KASAI KIYOSHI (JP)
YOSHIDA MASAKO (JP)
UENO YASUNORI (JP)
KASAI KIYOSHI (JP)
YOSHIDA MASAKO (JP)
Application Number:
PCT/JP2013/082777
Publication Date:
June 19, 2014
Filing Date:
December 06, 2013
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
International Classes:
C07D471/04; A61K31/519; A61K31/55; A61K31/553; A61K45/00; A61P5/06; A61P25/16; A61P43/00; C12N15/09
Domestic Patent References:
| WO2012124649A1 | 2012-09-20 |
Foreign References:
| JPS62298589A | 1987-12-25 | |||
| JPS6072891A | 1985-04-24 | |||
| JPS4826799A | 1973-04-09 | |||
| US4166182A | 1979-08-28 | |||
| US3752814A | 1973-08-14 | |||
| US4526892A | 1985-07-02 | |||
| US4452808A | 1984-06-05 | |||
| US3804849A | 1974-04-16 | |||
| US4886812A | 1989-12-12 | |||
| EP0250179A2 | 1987-12-23 |
Other References:
See also references of EP 2930175A4
HAPPE, S. ET AL., CNS DRUGS, vol. 18, no. 1, 2004, pages 27 - 36
CROSIGNANI, P. G. ET AL., EUR. J. OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol. 125, 2006, pages 152 - 164
PRIKHOJAN, A. ET AL., J. NEURAL TRANSM., vol. 107, 2000, pages 1159 - 1164
SETOLA, V. ET AL., MOL. PHARMACOL., vol. 63, 2003, pages 1223 - 1229
NEWMAN-TANCREDI A. ET AL., NAUNYN-SCHMIEDEBERG'S ARCH PHARMACOL, vol. 359, 1999, pages 447 - 453
KOGA K. ET AL., EUR J PHARMACOL, vol. 408, 2000, pages 249 - 255
HAPPE, S. ET AL., CNS DRUGS, vol. 18, no. 1, 2004, pages 27 - 36
CROSIGNANI, P. G. ET AL., EUR. J. OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol. 125, 2006, pages 152 - 164
PRIKHOJAN, A. ET AL., J. NEURAL TRANSM., vol. 107, 2000, pages 1159 - 1164
SETOLA, V. ET AL., MOL. PHARMACOL., vol. 63, 2003, pages 1223 - 1229
NEWMAN-TANCREDI A. ET AL., NAUNYN-SCHMIEDEBERG'S ARCH PHARMACOL, vol. 359, 1999, pages 447 - 453
KOGA K. ET AL., EUR J PHARMACOL, vol. 408, 2000, pages 249 - 255
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