Title:
NOVEL OPTICALLY ACTIVE BENZODIAZEPINE DERIVATIVE AND COMPOSITION COMPRISING SAME FOR INHIBITING DIABETIC PERIPHERAL NEUROPATHY
Document Type and Number:
WIPO Patent Application WO/2023/063722
Kind Code:
A1
Abstract:
The present invention relates to: a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof; a method for preparing the compound; and a pharmaceutical composition for preventing or treating diabetic peripheral neuropathy, comprising the compound or a pharmaceutically acceptable salt thereof as an active ingredient. A novel optically active benzodiazepine derivative compound of the present invention prevents degeneration of peripheral nerves by acting on Schwann cells to inhibit a neuronal axon degeneration process and dedifferentiation of Schwann cells, and thus can be effectively used for prevention or treatment of diabetic peripheral neuropathy. In addition, a method for preparing the compound according to the present invention enables eco-friendly production of the optically active compound at a low cost without using a metal catalyst.
Inventors:
KIM SUNG-GON (KR)
Application Number:
PCT/KR2022/015406
Publication Date:
April 20, 2023
Filing Date:
October 12, 2022
Export Citation:
Assignee:
UNIV KYONGGI IND & ACAD COOP FOUND (KR)
International Classes:
C07D243/10; A61K31/4709; A61K31/551; A61P25/00; A61P25/02; A61P25/28; C07D453/02
Foreign References:
| CN112679444A | 2021-04-20 | |||
| KR20220026168A | 2022-03-04 |
Other References:
LEE CHANG YOON, KWON YONG IL, JANG HYUN SUN, LEE SUMIN, CHUN YOO LIM, JUNG JUNYANG, KIM SUNG‐GON: "Organocatalytic Enantioselective [4+3]‐Cycloadditions of Azaoxyallyl Cations with 2‐Aminophenyl Enones", ADVANCED SYNTHESIS AND CATALYSIS, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 363, no. 17, 7 September 2021 (2021-09-07), Hoboken, USA, pages 4197 - 4203, XP093057113, ISSN: 1615-4150, DOI: 10.1002/adsc.202100676
KWON YONGIL, CHOI SUNYOUNG, JANG HYUN SUN, KIM SUNG-GON: "Rapid Access to Hindered α-Amino Acid Derivatives and Benzodiazepin-3-ones from Aza-Oxyallyl Cations", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 4, 21 February 2020 (2020-02-21), US , pages 1420 - 1425, XP093057114, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c00023
JIN QIAOMEI, ZHANG DONGJIAN, ZHANG JIAN: "Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones via cyclization of N -alkoxy α-halogenoacetamides with N -(2-chloromethyl)aryl amides", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 17, no. 45, 20 November 2019 (2019-11-20), pages 9708 - 9711, XP093057115, ISSN: 1477-0520, DOI: 10.1039/C9OB02260K
KWON YONGIL, CHOI SUNYOUNG, JANG HYUN SUN, KIM SUNG-GON: "Rapid Access to Hindered α-Amino Acid Derivatives and Benzodiazepin-3-ones from Aza-Oxyallyl Cations", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 4, 21 February 2020 (2020-02-21), US , pages 1420 - 1425, XP093057114, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c00023
JIN QIAOMEI, ZHANG DONGJIAN, ZHANG JIAN: "Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones via cyclization of N -alkoxy α-halogenoacetamides with N -(2-chloromethyl)aryl amides", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 17, no. 45, 20 November 2019 (2019-11-20), pages 9708 - 9711, XP093057115, ISSN: 1477-0520, DOI: 10.1039/C9OB02260K
Attorney, Agent or Firm:
AHN, Chang-woo (KR)
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